王长虹 研究员、博士生导师 研究领域 药物代谢和给药系统方向 主要从事中药活性成分体内过程及新型药物给药系统研究 教育背景 1982.09－1986.08 新疆医学院药学系 医学学士 1995.09－1998.08 新疆医科大学药剂学专业 药剂学硕士 1999.09－2002.08 新疆医科大学药剂学专业 理学博士 2002.12－2004.12 上海中医药大学中药研究所 博士后 工作经历 1986.09－2002.11 新疆医科大学第二附属医院 副教授 2002.12 - 今 上海中医药大学中药研究所 研究员 2013.10－2014.09 美国密西根大学药学院 高级访问学者 个人荣誉 上海市优秀学术带头人 研究成果 获教育部自然科学奖一等奖2项、上海市科技进步一等奖1项，新疆维吾尔自治区科技进步二等奖1项，新疆维吾尔自治区、新疆生产建设兵团和乌鲁木齐市科技进步三等奖3项； 先后主持或参加国家973计划子课题、国家自然基金重点项目、国家自然基金、上海市中药现代化专项、上海市科委基础研究重点项目、上海市纳米专项、上海市教育委员会科研创新项目等20余项；获国家新药证2项；发表科研论文220篇，其中SCI收录论文80余篇，总影响因子199.04分；申请专利10项，获得授权专利7项。 近期主要发表论文 1. Wei Liu, Xiaoyuan Shi, Yadi Yang, Xuemei Cheng, Qing Liu, Han Han, Baohua Yang, Chunyong He, Yongli Wang, Bo Jiang, Zhengtao Wang, Changhong Wang*. In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor. Plos One, 2015, DOI:10.1371/journal.pone.0122366 2. Yadi Yang, Xuemei Cheng*, Wei Liu, Guixin Chou, Zhengtao Wang, Changhong Wang*. Potent AChE and BChE inhibitors isolated from seeds of Peganum harmala Linn by a bioassay-guided fractionation. J Ethnopharmacol, 2015, 168:279�286 3. Pengfei Yue, Changhong Wang*, Jixiu Dan, Wei Liu, Zhenfeng Wu, Ming Yang. The importance of solidification stress on the redispersibility of solid nanocrystals loaded with harmine. International Journal of Pharmaceutics, 2015, 480(1-2): 107-115 4. Wei Liu, Xuemei Cheng, Yongli Wang, Shuping Li, Tianhui Zheng, Yingying Gao, Guofeng Wang, Shenglan Qi, Jingxin Wang, Jiayi Ni, Zhengtao Wang, Changhong Wang*. In vivo evaluation of the antitussive, expectorant and bronchodilating effects of extract and fractions from aerial parts of Peganum harmala Linn. J Ethnopharmacol, 2015, 162: 79�86 5. Baohua Yang, Wei Liu, Kaixian Chen, Zhengtao Wang, Changhong Wang*. Metabolism of Diosbulbin B in vitro and in vivo in Rats: Formation of Reactive Metabolites and Human Enzymes Involved. Drug Metabolism and Disposition. 2014, 42:1737�1750 (IF:3.334) 6. Liu Wei, Yang Yadi, Cheng Xuemei, Gong Can, Li Shuping, He Dandan, Yang Li, Wang Zhengtao, Wang Changhong*. Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 2014, 92: 215-220 7. Yang Tao, Sheng Huan-huan, Feng Nian-ping, Wei Hai, Wang Zheng-tao, Wang Chang-hong*. Preparation of Andrograhpolide-loaded Solid Lipid Nanoparticles and Its in intro and in vivo Evaluation: Characteristics, Release, Absorption, Transports, Pharmacokinetics and Anti-hyperlipidemic Activity. J Pharm Sci, 2013, 102:4414-4425. 8. Wang CH*, Li Y, Gao JG, He YQ, Xiong AZ, Yang L, Cheng XM, Ma YM, Wang ZT. The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS. Anal Bioanal Chem, 2011, 401:275-287 9. Yang T, Wang CH*, Chou GX, Wu T, Cheng XM, Wang ZT. New alkaloids from Capparis spinosa, Structure and X-ray crystallographic analysis. Food Chemistry, 2010, 123: 705-710. 10. He YQ, Yang L, Yang L, Liu HX, Zhang JW, Liu Y, Xiong AZ, Fong A, Lu YL, Wang CH*, Wang ZT*. Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids. Chem. Res. Toxicol. 2010, 23(3): 591-599. |
