陈万生教授

发布时间:2019-10-13浏览浏览:3703设置

姓名:陈万生

职称:教授

职务:上海中医药大学中药资源与生物技术中心主任

联系方式:chenws126@126.com

学历/学位:研究生/博士

  

  

研究领域/方向:基于药效物质的中药品质调控

教育背景:

1986/08-1991/07第二军医大学,药学系,理学学士

1991/08-1994/07第二军医大学,药学院,生药学硕士,导师:乔传卓教授

研究课题:知母的生药学研究

1997/08-2000/07第二军医大学,药学院,生药学博士,导师:乔传卓教授

研究课题:制首乌活性成分及品质评价

工作经历:

2018/06-至今上海中医药大学中药资源与生物技术中心主任

2005/04-至今第二军医大学长征医院,药学部主任、教授/主任药师,

第二军医大学代中药研究中心副主任,2007年获得博士生导师资格。

2000/08-2005/03第二军医大学药学院生药学教研室副主任,

讲师、副教授。

1994/08-1997/07第二军医大学药学院生药学教研室,助教,讲师。

所获得的人才称号:

入选国家杰出青年科学基金、上海市优秀学科带头人、上海市曙光学者、上海市青年科技启明星等人才计划。

个人荣誉称号:上海市优秀青年教师

近三年主要科研成果:

发表论文:

1)Xiao Y, Ji Q, Gao S, Tan H, Chen R, Li Q, Chen J, Yang Y, Zhang L*, Wang Z*, Chen W*, Hu Z. 2015. Combined transcriptome and metabolite profiling reveals that IiPLR1 plays an important role in lariciresinol accumulation in Isatis indigotica.Journal of Experimental Botany66(20): 6259-6271.

2)Jiang B, Li S, Liu W, Yang Y, Chen W, He D, Cheng X, Wang Z, Chen W*, Wang C*. 2015. Inhibitive activities detection of monoamine oxidases (MAO) a and B inhibitors in human liver MAO incubations by UPLCESI-MS/MS.Journal of Pharmaceutical & Biomedical Analysis115: 283-291.

3)Han J, Yi J, Liang F, Jiang B, Xiao Y, Gao S, Yang N, Hu H, Xie WF, Chen W*. 2015. X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db mice.Molecular & Cellular Endocrinology405(C): 63-73.

4)Han J, Yang N, Zhang F, Zhang C, Liang F, Xie W, Chen W*. 2015. Rhizoma Anemarrhenae extract ameliorates hyperglycemia and insulin resistance via activation of AMP-activated protein kinase in diabetic rodents.Journal of Ethnopharmacology172: 368-376.

5)Le J, Lu W, Xiong X, Wu Z*, Chen W*. 2015. Anti-Inflammatory Constituents from Bidens frondosa.Molecules20(10): 18496-18510.

6)Li C, Wu Z, Chen W*. 2015a. A new aromatic glucoside from stem bark of Illicium difengpi K.I.B. Et K.I.M.Natural Product Research29(19): 1793-1797.

7)Li C, Wu Z, Chen W*. 2015b. A New Amide from the Stem Bark of Illicium difengpi and its Anti-inflammatory Activity.Records of Natural Products9(2): 257-261.

8)La M, Feng Z, Gao S, Liu X, Wu Z, Sun L, Xia T, Chen W*. 2015. Constituent analysis and quality control of Lamiophlomis rotata by LC-TOF/MS and HPLC-UV.Journal of Pharmaceutical & Biomedical Analysis102(102): 366-376.

9)Peng Y, Zhang F, Tao H, Wang W, Sun L, Chen W, Wang C*. 2015. Simultaneous determination of multiple platycosides with a single reference standard in Platycodi Radix by highperformance liquid chromatography coupled with evaporative light scattering detection.Journal of Separation Science38(21): 3712-3719.

10)Liu X, Zhang F, Gao S, Jiang B, Chen W*. 2015. Metabolite profiling of Zi-Shen pill in rat biological specimens by UPLC-Q-TOF/MS.Chinese Journal of Natural Medicines13(2): 145-160.

11)Nie W, Tao X, Wei H, Chen WS*, Li B*. 2015. The BIM deletion polymorphism is a prognostic biomarker of EGFR-TKIs response in NSCLC: A systematic review and meta-analysis.Oncotarget6(28): 25696-25700.

12)Zhang L, Chen J, Zhou X, Chen X, Li Q, Tan H, Dong X, Xiao Y, Chen L, Chen W*. 2016. Dynamic metabolic and transcriptomic profiling of methyl jasmonate-treated hairy roots reveals synthetic characters and regulators of lignan biosynthesis inIsatis indigotica Fort.Plant Biotechnology Journal14(12): 2217-2227.

13)Nie W, Ge HJ, Yang XQ, Sun X, Huang H, Tao X, Chen WS*, Li B*. 2016. LncRNA-UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p.Cancer Letters371(1): 99-106.

14)Zhou Y, Wei S, Chen J, Tan H, Ying X, Li Q, Qian J, Gao S, Li C, Chen S, Zhang L*, Chen W*. 2016. SmMYC2a andSmMYC2b played similar but irreplaceable roles in regulating the biosynthesis of tanshinones and phenolic acids inSalvia miltiorrhiza.Scientific Reports6: 22852.

15)Zhang F, La M, Gong X, Gao S, Wu Z, Sun L, Tao X, Chen W*. 2016. Metabolite identification and pharmacokinetic study of Lamiophlomis rotata in rats.RSC Advances6(29): 24331-24339.

16)Zhang L, Li Q, Chen J, Chen W*. 2016. Computational identification and systematic classification of novel GRAS genes in Isatis indigotica.Chinese Journal of Natural Medicines14(3): 161-176.

17)Zhang L, Chen J, Li Q, Chen W*. 2016. Transcriptome-wide analysis of basic helix-loop-helix transcription factors in Isatis indigotica and their methyl jasmonate responsive expression profiling.Gene576(1): 150-159.

18)Wang Q, Wen Y, Xia T, Xiong X, Gao S, You C, Tao X, Zhang F*, Chen W*. 2016. Quantification of 18 amino acids in human plasma: Application in renal transplant patient plasma by targeted UHPLC-MS/MS.Bioanalysis8(13): 1337-1351.

19)Wu X, Xiong X, Lu W, Huang H, Shen Y, Wu Z*, Chen W*. 2016. New Sesquiterpenenoids from Ainsliaea yunnanensis.Molecules21(8): 1031.

20)Shu C, Chen X, Xia T, Zhang F, Gao S, Chen W*. 2016. LCMS/MS method for simultaneous determination of serum pcresyl sulfate and indoxyl sulfate in patients undergoing peritoneal dialysis.Biomedical Chromatography30(11): 1782-1788.

21)Shu C, Zeng T, Gao S, Xia T, Huang L, Zhang F*, Chen W*. 2016. LCMS/MS method for simultaneous determination of thalidomide, lenalidomide, cyclophosphamide, bortezomib, dexamethasone and adriamycin in serum of multiple myeloma patients.Journal of Chromatography B1028: 111-119.

22)Xia T, Gao S, Shu C, Wen Y, Yun Y, Tao X, Chen W*, Zhang F*. 2016. Analysis of amino acids in human blood using UHPLC-MS/MS: Potential interferences of storage time and vacutainer tube in pre-analytical procedure.Clinical Biochemistry49(18): 1372.

23)Ma R, Liu Q, Xiao Y, Zhang L, Qing L, Yin J*, Chen W*. 2016. The phenylalanine ammonia-lyase gene family in Isatis indigotica Fort.:Molecular cloning,characterization,and expression analysis.Chinese Journal of Natural Medicines14(11): 801-812.

24)Zhou Y, Zhou X, Li Q, Chen J, Xiao Y, Zhang L*, Chen W*. 2017. Molecular cloning, bioinformatics analysis, and transcriptional profiling of JAZ1 and JAZ2 from Salvia miltiorrhiza.Biotechnology & Applied Biochemistry64(1): 27.

25)Wang Z, Yun Y, Xie X, You C, Miao H, Zhang F, Gao S*, Chen W*. 2017. Comparison of LC-MS/MS vs chemiluminescent microparticle immunoassay in measuring the valproic acid concentration in plasma of epilepsy patients in a new perspective.Journal of Clinical Laboratory Analysis32(1): e22157.

26)Ma R, Xiao Y, Lv Z, Tan H, Chen R, Li Q, Chen J, Wang Y, Yin J*, Zhang L*, Chen W*. 2017. AP2/ERF transcription factor, Ii049, positively regulates lignan biosynthesis in Isatis indigotica through activating salicylic acid signaling and Lignan/Lignin pathway genes.Frontiers in Plant Science8: 1361.

27)Wang G, Chen J, Yi B, Tan H, Zhang L*, Chen W*. 2017. HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids inSalvia miltiorrhiza.Chinese Journal of Natural Medicines15(12): 917-927.

28)Zhou Z, Tan H, Li Q, Chen J, Gao S, Wang Y, Chen W*, Zhang L*. 2018. CRISPR/Cas9-mediated efficient targeted mutagenesis of RAS inSalvia miltiorrhiza.Phytochemistry148: 63.

29)Huang D, Wang X, Sun L, Chen W*, Sun L*. 2018.Two new phenylpropanoids from Penthorum chinense Pursh.Phytochemistry Letters doi.org/10.1016/j.phytol.2018.09.015.

  

         承担科研项目情况:

序号

项目类别

批准号

项目名称

起止

年月

金额

(万元)

进展

情况

1

国家科技重大专项子课题

2017ZX09101002-003-002

高产青蒿素的黄花蒿优良品系代谢工程育种研究

2017.1-2020.12

361.4

在研

2

国家自然科学基金重点项目

81830109

基于临床真实世界证据的中药质量标志物的发现与确认

  

2019.1-2023.12

294

在研

3

国家自然科学基金面上项目

31872665

转录因子IiWRKY34调控菘蓝优良品质形成的分子机制

2019.1-2022.12

59

在研

4

国家杰出青年科学基金

81325024

中药药效物质

2014.1-2017.12

320

结题

5

国家重大科学研究计划子课题

2015CB931803

肺癌在体分子分型的新型纳米分子成像探针基础研究

2015.01-2018.04

30

结题

6

国家科技部国际合作项目

S2015ZR1043

肿瘤个体化治疗新型生物标志物的发现与应用

2015.01-2017.12

200

结题

7

国家科技重大专项重大新药创制

2013ZX09507005

基于微流控芯片的新药研究开发关键技术

2013.01-2015.12

78.24

结题

8

国家自然科学基金面上项目

81470173

桔梗在升陷汤中发挥引经作用的药代动力学机制与物质基础

2015.01-2018.12

75

在研

9

上海申康医院发展中心

SHDC12015120

结直肠癌术后辅助化疗新型生物标志物的发现与应用

2016.01-2018.12

100

在研

10

军队质量标准研究课题项目

13ZJZ14

器官移植用系列特色制剂的研究及标准

2013.6.1-2015.12

31

结题

  

授权专利:

1)陈万生,李铁军,孙连娜,孙赫。知母提取物与黄柏提取物的组合物及其用途,专利号ZL200710040990.1

2)陈万生,孙赫,孙连娜,李铁军。知母提取物用于制备防治前列腺增生药物的用途ZL200710040991.6

3)娄子洋,陈万生。知母总皂苷提取物用于制备心肌缺血产品的用途,专利号ZL200510024312.7

4)伊佳,陈万生,李铁军,邱彦,孙连娜,毛俊琴。知母皂苷B-II用于制备抗抑郁产品的用途,专利号ZL 200810032324.8

5)陈万生,吴秋业,胡宏岗,宴菊芳,吴玮峰,叶飞,俞世冲,赵庆杰,但志刚,邹燕,徐建明,柴晓云。新的磺酰基取代的氧杂蒽酮类化合物及其制备方法与应用,专利号ZL200810036756.6

6)肖凯,姜远英,曹永兵,黄金灵,陈万生,丁雪鹰,蔺红伟。虎杖苷用于制备抗痴呆产品的用途,专利号ZL200810040338.4

7)孙连娜,席忠新,李霞,赵贵钧,王燕,陈万生。鼠曲草提取物在制备防治类风湿性关节炎药物中的应用,专利号ZL201110059384.0

8)陈万生,徐江平,殷学平,柴逸峰,周斌,乔传卓,张卫东。大黄素-8-O-b-D-葡萄糖苷的新用途,专利号ZL99119950.2

9)陈万生,李力,殷学平,杨根金,乔传卓,张卫东,陈海生。一种防治心脑血管疾病的四羟基二苯乙烯苷类新化合物,专利号ZL 99119853.0

10)陈万生,邱彦,关军,殷学平。蒲黄提取物及其制备方法和用途,专利号ZL 03115508.1

11)陈万生,邱彦,殷学平,陶朝阳。知母总皂苷用于制备防治脑卒中药物的用途,专利号ZL 03116824.8

12)陈万生,娄子洋,殷学平,陶朝阳,孙连娜。知母提取物及其制备方法和用途,专利号ZL 03115509.X

13)冯端浩,于雷,陈万生,娄子洋。具有抗乙肝病毒等活性的中药胡黄连提取物及制备方法,专利号ZL200510011487.4

14)孙连娜,陈万生,杨阳,张凤,来威,曹永兵,姜远英。甘西鼠尾草提取物在制备治疗肾小球肾炎药物中的应用,专利号ZL200710048139.3

15)孙连娜,黄豆豆,李君丽,韩军,梁凤英,陈万生。大环多酚化合物及其制备与在制药中的应用,专利号ZL201310610785.X

科研奖励成果

1)国家科学技术进步二等奖(2015):藏药现代化与独一味新药创制、资源保护及产业化示范.贾正平,李茂星,阙文彬、张汝学,张兆琳,陈万生,樊鹏程,马慧萍,才让扎西,陈世武,邱建国,张泉龙,马骏,李文斌,段志平

2)教育部高等学校科学研究优秀成果奖(科学技术)一等奖(2017):基于药效物质形成机制的中药品质调控技术体系及应用,陈万生,张磊,肖莹,陈军峰,谭何新,李卿,邸鹏,乔传卓,张汉明,孙连娜,丁如贤

 

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