杨 莉 研究员、博士生导师 研究领域 中药药效物质基础及质量标准 有毒中药安全性评价 教育背景 1997.09－2001.06 中国药科大学 中药制药专业 工学学士 2001.09－2006.06 中国药科大学 生药学专业 理学博士 2005.04－2006.04 日本富山大学 和汉药学专业 交流研修生 工作经历 2006.07－2008.06 上海中医药大学中药学博士后流动站 博士后 2008.07－2010.12 上海中医药大学中药研究所 副研究员 2009.10－2009.12 英国伦敦城市大学 访问学者 2011.01 - 今 上海中医药大学中药研究所 研究员 2012.03－2013.03 美国希望之城(City of Hope)国家医学中心 高级访问学者 2013.01 - 今 上海中医药大学中医方证与系统生物学研究中心研究员 个人荣誉 首批国家优秀青年基金获得者、教育部新世纪人才、上海市曙光学者、上海市青年科技启明星、上海市卫计委优秀青年人才 研究成果 获国家科技进步二等奖1项，教育部高等学校优秀成果自然科学一等奖2项，上海市科技进步一等奖2项。 承担包括国家自然科学优秀青年基金项目、科技部十二五“重大新药创制”课题等15项；发表科研论文90余篇，其中SCI收录论文66篇；获发明专利授权8项。 近期主要发表论文 1. Pengfei Li, Meng Qi, Haijun Hu, Qing Liu, Qiming Yang, Dandan Wang, Fujiang Gu, S.W. Annie Bligh, Zhengtao Wang and Li Yang. Structure-Inhibition Relationship of Phenylethanoid Glycosides on Angiotensin Converting Enzyme Using Ultra-Performance Liquid Chromatography-Tandem Quadrupole Mass Spectrometry. RSC Advances. 2015, 5: 51701-51707. 2. Han Han, Xiong Aizhen, He Chunyong, Liu Qing, Yang Li*, Wang Zhengtao*. Combination of UHPLC/Q-TOF-MS, NMR spectroscopy, and ECD calculation for screening and identification of reactive metabolites of gentiopicroside in humans; Analytical and Bioanalytical Chemsitry; 2014, 406: 1781-1793. 3. Xiong Aizhen, Yang Fan, Fang Lianxiang, Yang Li*, He Yuqi, Wan Yu-Jui Yvonne, Xu Ying, Qi Meng, Wang Xiuli, Yu Kate, Tsim Wah-Keung Karl, and Wang Zhengtao*. Metabolomic and Genomic Evidence for Compromised Bile Acid Homeostasis by Senecionine, a Hepatotoxic Pyrrolizidine Alkaloid. Chemical Research in Toxicology. 2014, 27(5): 775?786 4. Ding Lili, Li Jinmei, Song Baoliang, Xu Xiao, Wendong Huang, Zhang Binfeng, Tang Xiaowen, Qimeng, Yang Qimeng, Yang Qiaoling, Yang Li*, Wang Zhengtao*. Andrographolide Prevents High-Fat Diet-Induced Obesity in C57BL/6 Mice by Suppressing the Sterol Regulatory Element-Binding Protein Pathway. The Journal of Pharmacology and Experimental Therapeutics. 2014, 351(2):474-83 5. Xiong Yinhua, Xu Ying, Yang Li*, Wang Zhengtao*. Gas chromatography�mass spectrometry-based profiling of serum fatty acids in acetaminophen induced liver injured rats; Journal of Applied Toxicology; 2014, 34: 149-157. 6. Xu Ying, Yang Li*, Yang Fan, Xiong Yinhua, Wang Zhengtao*, Hu Zhibi. Metabolic profiling of fifteen amino acid in serum of chemical-induced liver injury rats by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry; Metabolomics; 2012,8,475-483. 7. Xiong Aizhen, Yang Li*, Yang Xuejing, Ji Lili, Wang Zaiyong, Chen Ying, Wang Xiuli, Wang Changhong, Wang Zhengtao*. UPLC-MS based metabolomics study on two Senecio herbs, Sececio scandens and S. Vulgaris: an approach for the differentiation of genetically closed species with similar morphology but different toxicity; Metabolomics; 2012, 8: 614-623. 8. Yang Fan, Xu Ying, Xiong Aizhen, He Yuqi, Yang Li*, Wan YJ Yvonne, Wang Zhengtao*. Evaluation of the protective effect of Rhei Radix et Rhizoma against α-naphthylisothiocyanate induced liver injury based on metabolic profile of bile acids. Journal of Ethnopharmacology; 2012, 144:599-604.9. Yang Li, Wang Yun, Wang Longxing, Xiao Hongbin, Wang Zhengtao*, Hu Zhibi. Rapid quantification of iridoid glycosides analogues in the formulated Chinese medicine Longdan Xiegan Decoction using high-performance liquid chromatography coulpled with mass spectromentry. Journal of Chromatography A, 2009, 1216: 2098-2103. 10. Yang Li, Xiong Aizhen, He Yuqi, Wang Zaiyong, Wang Changhong, Wang Zhengtao*, Li Wei, Yang Ling, Hu Zhibi. A Bile Acids Metabonomic Study on the CCl4- and ANIT- Induced Animal Models: Quantitative Analysis of 22 Bile Acids by UPLC-MS. Chemical Research in Toxicology. 2008, 21(12):2280-2288. |
