• 王辉俊
    副研究员
    研究方向:中药多糖化学与生物学
    邮箱:huijun.wang@outlook.com
    职务:硕士生导师
    电话:021-51322511
    学历学位:博士

个人简历

教育背景

   

2012.9 ~ 2015.7,上海中医药大学,中药学博士


2009.9 ~ 2012.7,上海中医药大学,中药学硕士


2005.9 ~ 2009.7,湘潭大学,药学学士

工作经历

   

2019.9 ~ 今,上海中医药大学中药研究所,副研究员


2017.11 ~ 2019.8,上海医药集团股份有限公司 中央研究院,高级工程师


2015.7 ~ 2017.10,上海医药集团股份有限公司中央研究院,工程师


期间2016.1 ~ 2018.11,中国科学院上海药物研究所博士后流动站和上海医药集团股份有限公司博士后工作站,博士后


2013.4 ~ 2015.1,英国Unilever Research Colworth, 博士联合培养


研究兴趣


中药多糖化学与生物学,新药研发。围绕中药多糖的化学结构、作用受体和构效关系开展研究,为中药药效物质基础研究、中药多糖的质量控制和新药研发奠定基础。


个人荣誉

   

2020年度上海中医药大学“杏林青年学者” 


2019年度上海市青年科技启明星


2017年度中国生物化学与分子生物学会糖复合物专业委员会“优秀青年人才”


2015年度上海市“优秀毕业生”


代表性论文

1. Chen J, Mei MS, Xu Y, Xiong S, Zhao Y, Liu R, Shi S, Wang H*, Wang S*. The impact of the methyl esters of homogalacturonan on cellular uptake dependent hypoglycemic activity in IR-HepG2 cells, Carbohydrate Polymers, 2022, 293, 119741.


2. Li N#, Yang F#, Su J, Shi S, Ordaz-Ortiz JJ, Cheng X, Xiong S, Xu Y, Wu J, Wang H*, Wang S*. Structure characterization of an arabinogalactan from Cynanchum atratum and its immune stimulatory activity on RAW264.7 cells. International Journal of Biological Macromolecules. 2022, 194:163-171.


3. Liu R, Shi S, Xiong S, Su J, Gan X, Wu J, Wang H*, Wang S*. Quality Markers of Dendrobium officinale by Oligosaccharide-Spectrum-Effect Relationships. Frontiers in Nutrition. 2022, 9:914380.


4. Wang H, Fowler MI, Messenger DJ, Ordaz-Ortiz JJ, Gu X, Shi S, Terry LA, Berry MJ, Lian G*, Wang S*. Inhibition of the intestinal postprandial glucose transport by gallic acid and gallic acid derivatives. Food & Function. 2021, 12(12):5399-5406.


5. Ren A#, Wang H#, Zhu H, Ye G, Li K, Chen D, Zeng T* Li H*. Glycoproteins From Rabdosia japonica var. glaucocalyx Regulate Macrophage Polarization and Alleviate Lipopolysaccharide-Induced Acute Lung Injury in Mice via TLR4/NF-κB Pathway. Frontiers in Pharmacology. 2021, 12:693298.


6. Cheng X#, Shi S#, Su J, Xu Y, Ordaz-Ortiz JJ, Li N, Wu J, Wang H*, Wang S*. Structural characterization of a heteropolysaccharide from fruit of Chaenomelese speciosa (Sweet) Nakai and its antitumor activity. Carbohydrate Polymers. 2020, 236: 116065.


7. Su J, Liu X, Li H, Cheng X, Shi S, Li N, Wu J, Xu Y, Liu R, Tian X, Wang H*, Wang S*. Hypoglycaemic effect and mechanism of an RG-II type polysaccharide purified from Aconitum coreanum in diet-induced obese mice. International Journal of Biological Macromolecules, 2020, 149, 359–370.


8. Wu R#, Wang H#, Lv X, Shen X*, Ye G*. Rapid Action of Mechanism Investigation of Yixin Ningshen Tablet in Treating Depression by Combinatorial Use of Systems Biology and Bioinformatics Tools. Journal of Ethnopharmacology, 2020, 257: 112827.                                                                                                        


9. Wang H#, Wu R#, Xie D#, Ding L, Lv X, Bian Y, Chen X, Nisma Lena BA, Wang S, Li K, Chen W, Ye G*, Sun M*. A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of Wei-Fu-Chun Tablet in the Treatment of Precancerous Lesions of Gastric Cancer. Frontiers in Pharmacology. 2020, 11:558471.


10. Wang H#, Guan Y#, Wu R, Lv X, Shen X*, Ye G*. UPLC-Q-TOF/MS characterization of efficacy substances on osteoblasts differentiation and function in rat serum after administration of Wang-Bi tablet. Biomedical Chromatography, 2019, e4628.


授权专利

1. 王辉俊;叶冠;吴若铭;柯樱. 瓜蒌皮多糖GLP-5-1、其制备方法及用途. ZL 201710160909.7.


2. Fowler, MI, Wang, Huijun. Edible composition. WO 2017/036926 A1.(PCT专利)


3. 王顺春;王辉俊;鲍斌;施松善;王峥涛;胡之璧. 一种从茶多糖中获取均一果胶多糖的方法及获得的均一果胶多糖. ZL201210172141.2.


科研项目

先后主持国家自然科学基金面上项目、上海市自然科学基金项目、上海市青年科技启明星计划项目、中国博士后科学基金项目等7项。



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