教育背景

2006.08－2009.06     中国科学院上海药物研究所   博士后

2002.09－2006.07    上海交通大学医学院     医学博士

1993.09－1996.07    中国科学院动物研究所     理学硕士

1987.09－1991.07    山东大学生物系        理学学士

工作经历

2016.01-今        上海中医药大学中药研究所 研究员，硕士生导师

2011.06–2015.12   上海中医药大学中药研究所 副研究员

2010.05–2011.05   美国艾伯特爱因斯坦医学院访问学者

2009.07–2010.04   上海中医药大学中药研究所 助理研究员

1996.08–2002.08   山东医科大学讲师

1991.08–1993.08   济南市自来水公司水质检验科化验员

（1）利用分子、细胞、组织和转基因动物模型，开展抗肠炎及结直肠癌天然产物药效活性和先导化合物发现研究；（2）从天然产物中发现抗肠炎和结直肠癌的活性化合物，并以其为探针开展新机理和新靶标发现研究。

1. Yue Bei, Gao Ruiyang, Lv Cheng, Yu Zhilun, Wang Hao, Geng Xiaolong, Wang Zhengtao, Dou Wei*. Berberine improves irinotecan-induced intestinal mucositis without impairing the anti-colorectal cancer efficacy of irinotecan by inhibiting bacterial β-glucuronidase. Frontiers in Pharmacology. 2021, 11: 774560.

2. Yue Bei, Gao Ruiyang, Wang Zhengtao, Dou Weri*. Microbiota-Host-Irinotecan Axis: A New Insight Toward Irinotecan Chemotherapy. Frontiers in Cellular and Infection Microbiology. 2021, 11: 710945.  

3. Ren Yijing, Lv Cheng, Zhang Jing, Zhang Beibei, Yue Bei, Luo Xiaoping, Yu Zhilun, Wang Hao, Ren Junyu, Wang Zhengtao, Dou Wei*. Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer model via activation of the MAPK-JNK/c-Jun signaling pathway. Molecular and Cellular Biochemistry. 2021, 476: 4387-4403.

4. Ren Junyu, Yue Bei, Wang Hao, Zhang Beibei, Luo Xiaoping, Yu Zhilun, Zhang Jing, Ren Yijing, Mani Sridhar, Wang Zhengtao, Dou Wei*. Acacetin ameliorates experimental colitis in mice via inhibiting macrophage inflammatory response and regulating the composition of gut microbiota. Frontiers in Physiology. 2021, 11: 577237. 

5. Luo Xiaoping, Yu Zhilun, Yue Bei, Ren Junyu, Zhang Jing, Mani Sridhar, Wang Zhengtao, Dou Wei*. Obacunone reduces inflammatory signaling and tumor occurrence in mice with chronic inflammation-induced colorectal cancer. Pharmaceutical Biology. 2020, 58: 886-897.

6. Yue Bei, Yu Zhilun, Lv Cheng, Geng Xiaolong, Wang Zhengtao, Dou Wei*. Regulation of the intestinal microbiota: An emerging therapeutic strategy for inflammatory bowel disease. World Journal of Gastroenterology. 2020, 26: 4378-4393. 

7. Yue Bei, Ren Junyu, Yu Zhilun, Luo Xiaoping, Ren Yijing, Zhang Jing, Mani, Sridhar, Wang Zhengtao, Dou Wei*. Pinocembrin alleviates ulcerative colitis in mice via regulating gut microbiota, suppressing TLR4/MD2/NF-kappaB pathway and promoting intestinal barrier. Bioscience Reports. 2020, 40: BSR20200986.

8. Yu Zhilun, Yue Bei, Ding Lili, Luo Xiaoping, Ren Yijing, Zhang Jing, Mani Sridhar, Wang Zhengtao, Dou Wei*. Activation of PXR by Alpinetin Contributes to Abrogate Chemically Induced Inflammatory Bowel Disease. Frontiers in Pharmacology. 2020, 11: 474.  

9. Luo Xiaoping, Yue Bei, Yu Zhilun, Ren Yijing, Zhang Jing, Ren Junyu, Wang Zhengtao, Dou Wei*. Obacunone Protects Against UC in Mice by Modulating Gut Microbiota, Attenuating TLR4/NF-κB Signaling Cascades, and Improving Disrupted Epithelial Barriers. Frontiers in Microbiology. 2020, 11: 497. 

10. Yue Bei, Luo Xiaoping, Yu Zhilun, Mani Sridhar, Wang Zhengtao, Dou Wei*. Inflammatory Bowel Disease: A Potential Result from the Collusion between Gut Microbiota and Mucosal Immune System. Microorganisms. 2019, 7: 440.  

1. 窦薇，王峥涛，张晶晶，丁丽丽，任改艳. 辛夷脂素的医药用途. ZL201210586005.8

2. 窦薇，王峥涛，张晶晶，丁丽丽, 张二云，孙阿宁. 豆蔻明的医药用途. ZL201210535781.5

3. 窦薇，王峥涛，丁丽丽, 张晶晶，孙阿宁，张二云. 土木香内酯在制备防治溃疡性结肠炎的药物或食品中的应用. ZL201210553437.9

4. 窦薇，王峥涛，张晶晶，杨莉，丁丽丽. 一种三七皂苷R1的用途. ZL201210179606.7

5. 发明人：窦薇，任改艳，孙阿宁，王峥涛，邓超，罗晓平. 升麻素在制备防治溃疡性结肠炎的药物或食品中的应用. ZL201510478295.8

6. 窦薇，王峥涛，张晶晶，丁丽丽,孙阿宁，张二云. 三七素的用途. ZL201410017982.5

7. 窦薇，任改艳，孙阿宁，王峥涛，邓超，罗晓平. 金合欢素在制备防治溃疡性结肠炎的药物或食品中的应用. ZL201510478293.9

8. 窦薇，任改艳，孙阿宁，王峥涛，邓超，罗晓平. 黄柏酮在制备防治溃疡性结肠炎的药物中的应用. ZL201510478406.5

9. 窦薇，任改艳，孙阿宁，王峥涛，邓超，罗晓平. 天麻素在制备防治溃疡性结肠炎的药物或食品中的应用. ZL201510478294.3

10. 窦薇，王峥涛，张晶晶，丁丽丽,孙阿宁，张二云. 三七皂苷Ft1的用途. ZL201410018161.3

11. 窦薇，王峥涛，孙阿宁，任改艳，张晶晶，丁丽丽. 荭草苷的用途. ZL201410018192.9

12. 窦薇，于之伦，王峥涛，岳备，任怡静，罗晓平. 豆蔻明在制备防治脱发的药物中的应用. ZL201711175783.7

13. 窦薇，于之伦，王峥涛，岳备，任怡静，罗晓平. 五味子醇甲的医药用途. ZL201810730068.3

14. 窦薇、于之伦、岳备、任怡静、罗晓平、张婧、任君宇、王峥涛. 一种防治脱发的草豆蔻药物组合物. ZL202110302352.2

15. 窦薇、于之伦、岳备、任怡静、张婧、任君宇、王峥涛. 去氢二异丁香酚在制备防治溃疡性结肠炎的药物中的应用. 专利号ZL2020110786891

先后主持国家自然基金面上项目、上海市自然基金项目、企业合作横向课题等10余项。