教育背景

2003.08－2007.05    美国路易斯安娜州立大学     理学博士

1997.09－2000.07    上海中医药大学             理学硕士

1993.09－1997.07    南京大学                    理学学士

工作经历

2011.02-今         上海中医药大学中药研究所 研究员，博士生导师

2007.08－2010.12    美国Pennington生物医学研究中心   博士后

2000.08-2003.07    上海中医药大学中药研究所  助研

中药复方及其活性成分在精神类疾病（抑郁）、老年痴呆、帕金森、自身免疫神经退行性疾病（多发性硬化症）、睡眠不足综合征以及心脑血管等疾病中作用机理及新药开发研究。

个人荣誉

 2024年度东方英才（上海市优秀学术带头人）、2013年度上海市高校特聘教授（东方学者）、2011年度上海市浦江学者

获奖情况

国家科学进步二等奖（2007，名列第4位）

上海市科技进步一等奖（2006，名列第4位）

上海市科技进步二等奖（2024，名列第3位）

中国民族医药学会科学技术一等奖（2024，名列第5位）

1. Jinfeng Yuan, Yanlin Tao, Mengxue Wang, Yufeng Chen, Xinyan Han, Hui Wu*, Hailian Shi, Fei Huang, Xiaojun Wu*. Astragaloside II, a natural saponin, facilitates remyelination in demyelination neurological diseases via p75NTR receptor mediated β-catenin/Id2/MBP signaling axis in oligodendrocyte precursor cells. J Adv Res, 2026, 80: 577-591.

2. Minglv Fang#, Ying Liu#, Yongli Han#, Yashi Xu, Jing Yu, Yingxuan Yan, Zhigang Jin*, Xiaojun Wu*, Cheng Huang*, Shengjie Fan*. Plumbagin ameliorates multiple sclerosis by inducing DDX3X-mediated stress granule assembly in mice. Pharmacol Res, 2026, May 20, 10825.

3. Xueqing Xie#, Hongyao Ge#, Xianrun Hu, Xuan Gao, Yingying Song, Longfei Xie, Hui Wu, Fei Huang, Changhong Wang*, Hailian Shi*, Xiaojun Wu*. Shenqi Oral Liquid regulates reactive oxygen species production by modulating autophagy, thereby regulating mitochondrial dynamics in cardiomyocytes and alleviating chroni heart falure in mice via adenosine 5’-monophosphate-activated protein kinase/mechanistic target of rapamycin axis. J Ethnopharmacol, 2026, 367:121660. 

4. Lijun Zhang, Jing Yu, Xiaoyan Gao, Yingxuan Yan, Xinyi Wang, Hang Shi, Minglv Fang, Ying Liu, Young-Bum Kim, Huanhu Zhu, Xiaojun Wu*, Cheng Huang*, Shengjie Fan*. Targeting farnesoid X receptor as aging intervention therapy. Acta Pharm Sin B, 2025 , Mar, 15(3): 1359-1382.

5. Chenyang Ni#, Lupeng Wang#, Yuyan Bai, Fei Huang, Hailian Shi, Hui Wu*, Xiaojun Wu*, Jin Huang*. Taurochenodeoxycholic acid activates autophagy and suppresses inflammatory responses in microglia of MPTP-induced Parkinson’s disease mice via AMPK/mTOR, AKT/NFκB and Pink1/Parkin signaling pathways mediated by Takeda G protein-coupled receptor 5. Free Rad Biol Med, 2025, Aug 1, 235: 347-363.

6. Liu Yang#, Xinyan Han#, Mengxue Wang, Xiaojuan Zhang, Lupeng Wang, Nuo Xu, Hui Wu, Hailian Shi, Weidong Pan*, Fei Huang*, Xiaojun Wu*. Early growth response gene 1 benefits autoimmune disease by promoting regulatory T cell differentiation as a regulator of Foxp3. Research, 2025, Apr 15, 8: 0662

7. Ning Li#, Xinyan Han#, Min Ruan#, Fei Huang, Liu Yang, Tianhao Xu, Huijun Wang, Juan Su, Hui Wu, Songshan Shi, Yongjun Wang*, Xiaojun Wu*, Shunchun Wang*. Prebiotic inulin controls Th17 cells mediated central nervous system autoimmunity through modulating the gut microbiota and and short chain fatty acids. Gut Microbes, 2024, 16(1): 2402547.

8. Nuo Xu#, Xinyan Han#, Xiaojuan Zhang, Junhao Wang, Jinfeng Yuan, Mengxue Wang, Hui Wu, Fei Huang, Hailian Shi, Liu Yang*, Xiaojun Wu*. Huangqi-Guizhi-Wuwu Decoction regulates differentiation of CD4⁺ T cell and prevents against experimental autoimmune encephalomyelitis progression in mice. Phytomedicine, 2024, Mar, 125: 155239 .

9. Yanlin Tao#, Houyuan Zhou#, Zikang Li, Hui Wu, Fanggeng Wu, Zhiguo Miao, Hailian Shi, Fei Huang*, Xiaojun Wu*. TGR5 deficiency-induced anxiety and depression-like behaviors: the role of gut microbiota dysbiosis. J Affect Disord, 2024, Jan 1, 344: 219-232 .

10. Mingzhu Yu, Qiaoling Pan, Wenbiao Li, Tingting Du, Fei Huang, Hui Wu, Yixin He, Xiaojun Wu*, Hailian Shi*. Isoliquiritigenin inhibits gastric cancer growth through suppressing GLUT4 mediated glucose uptake and inducing PDHK1/PGC-1α mediated energy metabolic collapse. Phytomedicine, 2023, Dec, 121: 155045. 

1. 吴晓俊，王峥涛，黄菲，郑方，周强。胆汁酸成分及熊胆的医药用途，ZL201610131100.7

2. 吴晓俊，王峥涛，曹秦，秦立悦，吴辉，石海莲，张蓓蓓。紫檀烷苷的医药用途，ZL201410838023.X

3. 吴晓俊，胡之璧，王峥涛，黄菲。黄芪甲苷的医药用途。ZL201310240120.4

4. 吴晓俊，胡之璧，王峥涛，黄菲。黄芪总皂苷的医药用途。ZL201310250408.X

5. 吴晓俊，王峥涛，胡之璧，贺一新，高艳。一种黄芪甲苷的新用途。ZL201310002150.1

6. 吴晓俊，刘涤，赵淑娟，胡之璧。一种提高黄芪毛状根中黄芪多糖的方法。ZL 02155192.8

先后承担科技部重点研发计划子课题、国家自然基金面上项目、教育部博士点专项重点项目、上海市自然科学基金、上海市教委重点项目、上海市卫计委中医药发展三年行动计划等20余项，并承担企业合作横向课题10余项。

兼任中国中西医结合学会临床药理与毒理专业委员会委员、上海市药学会药理学专业委员会委员、上海市中西医结合学会神经内分泌专业委员会委员、上海市免疫学会中医药免疫专委会委员、上海市中西医结合学会药物专业委员会委员、上海市衰老与退行性疾病学会中西医结合分会委员等。