教育背景

2003.08－2007.05    美国路易斯安娜州立大学     理学博士

1997.09－2000.07    上海中医药大学             理学硕士

1993.09－1997.07    南京大学                    理学学士

工作经历

2011.02-今         上海中医药大学中药研究所 研究员，博士生导师

2007.08－2010.12    美国Pennington生物医学研究中心   博士后

2000.08-2003.07    上海中医药大学中药研究所  助研

中药复方及其活性成分抗精神类疾病（抑郁）、老年痴呆、帕金森、自身免疫神经退行性疾病（多发性硬化症）、睡眠不足综合征等疾病中作用机理及新药开发研究。

个人荣誉

 2013年度上海市高校特聘教授（东方学者）、2011年度上海市浦江学者

获奖情况

国家科学进步二等奖（2007，名列第4位）

上海市科技进步一等奖（2006，名列第4位）

1. Yuan J，Tao Y, Wang M, Huang Fei*, Wu X*. Natural compounds as potential therapeutic candidates for multiple sclerosis: emerging preclinical evidence. Phytomedicine, 2023，Dec, 155248

2. Xu N#, Han X#, Zhang X, Wang J, Yuan J, Wang M, Wu Hui, Huang Fei, Shi H, Yang L*, Wu X*. Huangqi-Guizhi-Wuwu Decoction regulates differentiation of CD4⁺ T cell and alleviates experimental autoimmune encephalomyelitis in mice. Phytomedicine, 2023, 155239

3. Tao Y#, Zhou H#, Li Z, Wu H, Wu F, Miao Z, Shi H, Huang F*, Wu X*. TGR5 deficiency-induced anxiety and depression-like behaviors: the role of gut microbiota dysbiosis. 2024, Oct 13, J Affect Disord, 344: 219-232

4. Lan Y#, Han X#, Yang Liu*, Huang Fei, Shi H, Wu H, Hu Z*, Wu X*. Early growth response gene-1 deficiency interrupts TGFβ1 signaling activation and aggravates neurodegeneration in experimental autoimmune encephalomyelitis mice. Neurosci Bull, 2023, Sep 19, doi: 10.1007/s12264-023-01111-z

5. Yu M, Pan Q, Li W, Du T, Huang F, Wu H, He Y, Wu X*, Shi H*. Isoliquiritigenin inhibits gastric cancer growth through suppressing GLUT4 mediated glucose uptake and inducing PDHK1/PGC-1α mediated energy metabolic collapse. Phytomedicine, 2023, 121: 155045

6. Han X #, Xu N, Yuan J, Wu H, Shi H, Yang L*, Wu X*.Total flavonoid of Astragalus inhibit activated CD4+ T cells and regulate differentiation of Th17/Th1/Treg cells in experimental autoimmune encephalomyelitis mice by JAK/STAT and NFκB signaling pathways. Am J Chin Med, 2023, Jun 30, 51(5): 1233-1248

7. Li H#, Gao M#, Chen Z, Zhou Z, Li W, Zhang X, Jiang X, Luo L, Li F, Wang G, Zhang Y, Huang X, Zhu J*, Fan S*, Wu X*, Huang C*. Hordenine improves Parkinsonian-like motor deficits in mice and nematodes by activating dopamine D2 receptor-mediated signaling. Phytother Res, 2023, Aug，37(8):3296-3308

8. Cao Y#, Li M#, Gu L, Zhao X, Zhou A，Miao Y，Wu Y，Ke Z，Hu R*，Wang Z*，Wu X*. Chinese traditional formula Kaixin San suppressed ferroptosis of hippocampal neurons and cardiomyocytes in mice with paradoxical sleep deprivation. J Ethnopharmacol, 2023，Mar, 304:116034

9. Bai Y#, Zhou J#, Zhu H, Tao Y, Wang L, Yang L, Wu H, Huang F*, Shi H, Wu X*. Isoliquiritigenin rescues microglia-mediated neuroinflammation in models of Parkinson's disease via JNK/AKT/NFκB signaling pathway. Phytother Res, 2023, Mar;37(3):848-859

10. Gao Z#, Wang G#, Chen Y, Cai J，Feng A, Fang J, Xu Q*, Wu X*. Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX4 signaling pathway. Food Sci Hum Well, 2024, 13 doi.org/10.26599/FSHW.2022.9250035

11. Wang L#, Bai Y#, Tao Y, Shen W, Zhou H, He Y, Wu H, Huang F, Shi H, Wu X*. Bear bile powder alleviates Parkinson's disease-like behavior in mice by inhibiting astrocyte-mediated neuroinflammation. Chin J Nat Med, 2023, Sep, 21(9):710-720

12. Wang G, Chen Z, Song Y, Wu H, Chen M, Lai S, Wu X*. Xueshuantong injection alleviates cerebral microcirculation disorder in middle cerebral artery occlusion/reperfusion rats by suppressing inflammation via JNK mediated JAK2/STAT3 and NF-κB signaling pathways. J Ethnopharmacol, 2022, Nov 15, 298：115592

13. Yuan J, Tao Y, Xu N, Han X, Yang L, Liang J, Jin H, Zhang X, Wu H, Shi H, Huang F, Wu X*. Total astragalosides promote oligodendrocyte precursor cell differentiation and enhance remyelination in cuprizone-induced mice through suppression of Wnt/β-catenin signaling pathway. J Ethnopharmacol, 2022, Nov 15, 298：115622

14. Chen Z, Wang G, Xie X, Liu H, Liao J, Shi H, Chen M, Lai S, Wang Z*, Wu X*. Ginsenoside Rg5 allosterically interacts with P2RY₁₂ and ameliorates deep venous thrombosis by counteracting neutrophil NETosis and inflammatory response. Front Immunol, 2022，Aug12, 13:918476.

15. Han X, Chen Z, Yuan J, Wang G, Han X, Yang L*, Wu H, Shi H, Chou G, Wu X*. Artemisia annua water extract attenuates DNCB-induced atopic dermatitis by restraining Th2 cell mediated inflammatory responses in BALB/c mice. J Ethnopharmacol, 2022, 291: 115160.

16. Zhu H#, Wang G#, Bai Y, Tao Y, Wang L, Yang L, Wu H, Huang F*, Shi H, Wu X*. Natural bear bile powder suppresses neuroinflammation in lipopolysaccharide-induced mice via regulating TGR5/AKT/NF-κB signaling pathway. J Ethnopharmacol, 2022, 289:115063.

17. Zhu H#, Bai Y#, Wang G, Su Y, Tao Y, Wang L, Yang L, Wu H, Huang F*, Shi H, Wu X*. Hyodeoxycholic acid inhibits lipopolysaccharide-induced microglia inflammatory responses through regulating TGR5/AKT/NF-κB signaling pathway. J Psychopharmacol, 2022,36(7):849-859.

18. Cao Y, Li Q, Yang Y, Ke Z, Chen S, Wu H, Fan W, Yuan J, Li M, Wang Z*, Wu X*. Cardioprotective effect of stem-leaf saponins from Panax notoginseng on mice with sleep deprivation by inhibiting abnormal autophagy through PI3K/Akt/mTOR pathway. Front Cardiovas Med, 2021, 8:694219.

19. Cao Y, Li Q, Zhou A, Ke Z, Chen S, Li M, Gong Z*, Wang Z*, Wu X*. Notoginsenoside R1 reverses abnormal autophagy in hippocampal neuron of mice with sleep deprivation through melatonin receptor 1A. Front Pharmacol, 2021, Sep 16, 12:719313.

20. Fan W#, Zhang B#, Wu C, Wu H, Wu J, Wu S, Zhang J, Yang X, Yang L*, Hu Z*, Wu X*. Plantago asiatica L. seeds extract protects cardiomyocyte injury in isoproterenol-induced cardiac hypertrophy by inhibiting excessive autophagy and apoptosis in mice. Phytomedicine, 2021, 91: 153681.

21. Wang P#, Jin J#, Liang X, Yu M, Yang C, Huang F, Wu H, Zhang B, Fei X, Wang Z, Xu R, Shi H*, Wu X*. Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axix-mediated energy metabolism reprogramming. Acta Pharmacol Sin, 2021, 43(6):1581-1593.

22. Liang X#, Wang P#, Yang C, Huang F, Wu H, Shi H*, Wu X*. Galangin inhibits gastric cancer growth through enhancing STAT3 mediated ROS production. Front Pharmacol, 2021, April 26, 12:646628.

23. Huang F, Wu X*. Brain neurotransmitter modulation by gut microbiota in anxiety and depression. Front Cell Dev Biol, 2021, 9:649103. 

24. Yang L#, Han X#, Xing F#, Wu H, Shi H, Huang F, Xu Q*, Wu X*. Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFκB signaling pathway. Phytomedicine, 2021, 80:153385.

25. Li H#, Feng Y#, Chen Z, Jiang X, Zhou Z, Yuan J, Li F, Zhang Y, Huang X, Fan S*, Wu X*, Huang C*. Pepper component 7-ethoxy-4-methylcoumarin, a novel dopamine D2 receptor agonist, ameliorates experimental Parkinson’s disease in mice and Caenorhabditis elegans. Pharmcol Res, 2021, 163:105220. 

26. Cao Y, Yang Y, Wu H, Lu Y, Wu S, Liu L, Wang C, Huang F, Shi H, Zhang B, Wu X*, Wang Z*. Stem-leaf saponins from Panax notoginseng counteracts aberrant autophagy and apoptosis in hippocampal neurons of mice with cognitive impairment induced by sleep deprivation. J Ginseng Res, 2020, May, 44(3): 442-452.

27. Yang L, Han X, Yuan J, Xing F, Hu Z, Huang F, Wu H, Shi H, Zhang T*, Wu X*. Early astragaloside IV administration attenuates experimental autoimmune encephalomyelitis in mice by suppressing the maturation and function of dendritic cells. Life Sci, 2020, Feb19:117448.

28. Cao Y, Li QL, Liu LL, Wu H, Huang F, Wang CH, Lan YY, Zheng F, Xing FP, Zhou Q, Li Q, Shi HL, Zhang BB, Wang Z*, Wu X*. Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation. Brit J Pharmcol, 2019, May,176(9): 1282-1297.

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2. 吴晓俊，王峥涛，曹秦，秦立悦，吴辉，石海莲，张蓓蓓。紫檀烷苷的医药用途，ZL201410838023.X

3. 吴晓俊，胡之璧，王峥涛，黄菲。黄芪甲苷的医药用途。ZL201310240120.4

4. 吴晓俊，胡之璧，王峥涛，黄菲。黄芪总皂苷的医药用途。ZL201310250408.X

5. 吴晓俊，王峥涛，胡之璧，贺一新，高艳。一种黄芪甲苷的新用途。ZL201310002150.1

6. 吴晓俊，刘涤，赵淑娟，胡之璧。一种提高黄芪毛状根中黄芪多糖的方法。ZL 02155192.8

先后承担国家自然基金面上项目、科技部国家重点研发计划子课题、教育部博士点专项重点项目、上海市自然科学基金、上海市教委重点项目、上海市卫计委中医药发展三年行动计划等课题10余项，并承担企业合作横向课题10余项。

兼任中国中西医结合学会临床药理与毒理专业委员会委员、上海市药学会药理学专业委员会委员、上海市中西医结合学会神经内分泌专业委员会委员、上海市免疫学会中医药免疫专委会委员、《中药药理与临床》杂志编委等。