• 吴晓俊
    研究员
    研究方向:中药神经精神药理
    邮箱:xiaojunwu320@126.com
    职务:博士生导师
    电话:021-51322578
    学历学位:博士

个人简历

教育背景

   

2003.08-2007.05    美国路易斯安娜州立大学     理学博士


1997.09-2000.07    上海中医药大学             理学硕士


1993.09-1997.07    南京大学                    理学学士

工作经历

   

2011.02-今         上海中医药大学中药研究所 研究员,博士生导师


2007.08-2010.12    美国Pennington生物医学研究中心   博士后


2000.08-2003.07    上海中医药大学中药研究所  助研


研究兴趣

中药复方及其活性成分抗精神类疾病(抑郁)、老年痴呆、帕金森、自身免疫神经退行性疾病(多发性硬化症)、睡眠不足综合征等疾病中作用机理及新药开发研究。


个人荣誉

   

 2013年度上海市高校特聘教授(东方学者)、2011年度上海市浦江学者


获奖情况

   

国家科学进步二等奖(2007,名列第4位)


上海市科技进步一等奖(2006,名列第4位)


代表性论文

1. Yuan JTao Y, Wang M, Huang Fei*, Wu X*. Natural compounds as potential therapeutic candidates for multiple sclerosis: emerging preclinical evidence. Phytomedicine, 2023Dec, 155248

2. Xu N#, Han X#, Zhang X, Wang J, Yuan J, Wang M, Wu Hui, Huang Fei, Shi H, Yang L*, Wu X*. Huangqi-Guizhi-Wuwu Decoction regulates differentiation of CD4+ T cell and alleviates experimental autoimmune encephalomyelitis in mice. Phytomedicine, 2023, 155239

3. Tao Y#, Zhou H#, Li Z, Wu H, Wu F, Miao Z, Shi H, Huang F*, Wu X*. TGR5 deficiency-induced anxiety and depression-like behaviors: the role of gut microbiota dysbiosis. 2024, Oct 13, J Affect Disord, 344: 219-232

4. Lan Y#, Han X#, Yang Liu*, Huang Fei, Shi H, Wu H, Hu Z*, Wu X*. Early growth response gene-1 deficiency interrupts TGFβ1 signaling activation and aggravates neurodegeneration in experimental autoimmune encephalomyelitis mice. Neurosci Bull, 2023, Sep 19, doi: 10.1007/s12264-023-01111-z

5. Yu M, Pan Q, Li W, Du T, Huang F, Wu H, He Y, Wu X*, Shi H*. Isoliquiritigenin inhibits gastric cancer growth through suppressing GLUT4 mediated glucose uptake and inducing PDHK1/PGC-1α mediated energy metabolic collapse. Phytomedicine, 2023, 121: 155045

6. Han X #, Xu N, Yuan J, Wu H, Shi H, Yang L*, Wu X*.Total flavonoid of Astragalus inhibit activated CD4+ T cells and regulate differentiation of Th17/Th1/Treg cells in experimental autoimmune encephalomyelitis mice by JAK/STAT and NFκB signaling pathways. Am J Chin Med, 2023, Jun 30, 51(5): 1233-1248

7. Li H#, Gao M#, Chen Z, Zhou Z, Li W, Zhang X, Jiang X, Luo L, Li F, Wang G, Zhang Y, Huang X, Zhu J*, Fan S*, Wu X*, Huang C*. Hordenine improves Parkinsonian-like motor deficits in mice and nematodes by activating dopamine D2 receptor-mediated signaling. Phytother Res, 2023, Aug37(8):3296-3308

8. Cao Y#, Li M#, Gu L, Zhao X, Zhou AMiao YWu YKe ZHu R*Wang Z*Wu X*. Chinese traditional formula Kaixin San suppressed ferroptosis of hippocampal neurons and cardiomyocytes in mice with paradoxical sleep deprivation. J Ethnopharmacol, 2023Mar, 304:116034

9. Bai Y#, Zhou J#, Zhu H, Tao Y, Wang L, Yang L, Wu H, Huang F*, Shi H, Wu X*. Isoliquiritigenin rescues microglia-mediated neuroinflammation in models of Parkinson's disease via JNK/AKT/NFκB signaling pathway. Phytother Res, 2023, Mar;37(3):848-859

10. Gao Z#, Wang G#, Chen Y, Cai JFeng A, Fang J, Xu Q*, Wu X*. Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX4 signaling pathway. Food Sci Hum Well, 2024, 13 doi.org/10.26599/FSHW.2022.9250035

11. Wang L#, Bai Y#, Tao Y, Shen W, Zhou H, He Y, Wu H, Huang F, Shi H, Wu X*. Bear bile powder alleviates Parkinson's disease-like behavior in mice by inhibiting astrocyte-mediated neuroinflammation. Chin J Nat Med, 2023, Sep, 21(9):710-720

12. Wang G, Chen Z, Song Y, Wu H, Chen M, Lai S, Wu X*. Xueshuantong injection alleviates cerebral microcirculation disorder in middle cerebral artery occlusion/reperfusion rats by suppressing inflammation via JNK mediated JAK2/STAT3 and NF-κB signaling pathways. J Ethnopharmacol, 2022, Nov 15, 298115592

13. Yuan J, Tao Y, Xu N, Han X, Yang L, Liang J, Jin H, Zhang X, Wu H, Shi H, Huang F, Wu X*. Total astragalosides promote oligodendrocyte precursor cell differentiation and enhance remyelination in cuprizone-induced mice through suppression of Wnt/β-catenin signaling pathway. J Ethnopharmacol, 2022, Nov 15, 298115622

14. Chen Z, Wang G, Xie X, Liu H, Liao J, Shi H, Chen M, Lai S, Wang Z*, Wu X*. Ginsenoside Rg5 allosterically interacts with P2RY12 and ameliorates deep venous thrombosis by counteracting neutrophil NETosis and inflammatory response. Front Immunol, 2022Aug12, 13:918476.

15. Han X, Chen Z, Yuan J, Wang G, Han X, Yang L*, Wu H, Shi H, Chou G, Wu X*. Artemisia annua water extract attenuates DNCB-induced atopic dermatitis by restraining Th2 cell mediated inflammatory responses in BALB/c mice. J Ethnopharmacol, 2022, 291: 115160.

16. Zhu H#, Wang G#, Bai Y, Tao Y, Wang L, Yang L, Wu H, Huang F*, Shi H, Wu X*. Natural bear bile powder suppresses neuroinflammation in lipopolysaccharide-induced mice via regulating TGR5/AKT/NF-κB signaling pathway. J Ethnopharmacol, 2022, 289:115063.

17. Zhu H#, Bai Y#, Wang G, Su Y, Tao Y, Wang L, Yang L, Wu H, Huang F*, Shi H, Wu X*. Hyodeoxycholic acid inhibits lipopolysaccharide-induced microglia inflammatory responses through regulating TGR5/AKT/NF-κB signaling pathway. J Psychopharmacol, 2022,36(7):849-859.

18. Cao Y, Li Q, Yang Y, Ke Z, Chen S, Wu H, Fan W, Yuan J, Li M, Wang Z*, Wu X*. Cardioprotective effect of stem-leaf saponins from Panax notoginseng on mice with sleep deprivation by inhibiting abnormal autophagy through PI3K/Akt/mTOR pathway. Front Cardiovas Med, 2021, 8:694219.

19. Cao Y, Li Q, Zhou A, Ke Z, Chen S, Li M, Gong Z*, Wang Z*, Wu X*. Notoginsenoside R1 reverses abnormal autophagy in hippocampal neuron of mice with sleep deprivation through melatonin receptor 1A. Front Pharmacol, 2021, Sep 16, 12:719313.

20. Fan W#, Zhang B#, Wu C, Wu H, Wu J, Wu S, Zhang J, Yang X, Yang L*, Hu Z*, Wu X*. Plantago asiatica L. seeds extract protects cardiomyocyte injury in isoproterenol-induced cardiac hypertrophy by inhibiting excessive autophagy and apoptosis in mice. Phytomedicine, 2021, 91: 153681.

21. Wang P#, Jin J#, Liang X, Yu M, Yang C, Huang F, Wu H, Zhang B, Fei X, Wang Z, Xu R, Shi H*, Wu X*. Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axix-mediated energy metabolism reprogramming. Acta Pharmacol Sin, 2021, 43(6):1581-1593.

22. Liang X#, Wang P#, Yang C, Huang F, Wu H, Shi H*, Wu X*. Galangin inhibits gastric cancer growth through enhancing STAT3 mediated ROS production. Front Pharmacol, 2021, April 26, 12:646628.

23. Huang F, Wu X*. Brain neurotransmitter modulation by gut microbiota in anxiety and depression. Front Cell Dev Biol, 2021, 9:649103. 

24. Yang L#, Han X#, Xing F#, Wu H, Shi H, Huang F, Xu Q*, Wu X*. Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFκB signaling pathway. Phytomedicine, 2021, 80:153385.

25. Li H#, Feng Y#, Chen Z, Jiang X, Zhou Z, Yuan J, Li F, Zhang Y, Huang X, Fan S*, Wu X*, Huang C*. Pepper component 7-ethoxy-4-methylcoumarin, a novel dopamine D2 receptor agonist, ameliorates experimental Parkinsons disease in mice and Caenorhabditis elegans. Pharmcol Res, 2021, 163:105220. 

26. Cao Y, Yang Y, Wu H, Lu Y, Wu S, Liu L, Wang C, Huang F, Shi H, Zhang B, Wu X*, Wang Z*. Stem-leaf saponins from Panax notoginseng counteracts aberrant autophagy and apoptosis in hippocampal neurons of mice with cognitive impairment induced by sleep deprivation. J Ginseng Res, 2020, May, 44(3): 442-452.

27. Yang L, Han X, Yuan J, Xing F, Hu Z, Huang F, Wu H, Shi H, Zhang T*, Wu X*. Early astragaloside IV administration attenuates experimental autoimmune encephalomyelitis in mice by suppressing the maturation and function of dendritic cells. Life Sci, 2020, Feb19:117448.

28. Cao Y, Li QL, Liu LL, Wu H, Huang F, Wang CH, Lan YY, Zheng F, Xing FP, Zhou Q, Li Q, Shi HL, Zhang BB, Wang Z*, Wu X*. Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation. Brit J Pharmcol, 2019, May,176(9): 1282-1297.


授权专利

1. 吴晓俊,王峥涛,黄菲,郑方,周强。胆汁酸成分及熊胆的医药用途,ZL201610131100.7


2. 吴晓俊,王峥涛,曹秦,秦立悦,吴辉,石海莲,张蓓蓓。紫檀烷苷的医药用途,ZL201410838023.X


3. 吴晓俊,胡之璧,王峥涛,黄菲。黄芪甲苷的医药用途。ZL201310240120.4


4. 吴晓俊,胡之璧,王峥涛,黄菲。黄芪总皂苷的医药用途。ZL201310250408.X


5. 吴晓俊,王峥涛,胡之璧,贺一新,高艳。一种黄芪甲苷的新用途。ZL201310002150.1


6. 吴晓俊,刘涤,赵淑娟,胡之璧。一种提高黄芪毛状根中黄芪多糖的方法。ZL 02155192.8


科研项目

先后承担国家自然基金面上项目、科技部国家重点研发计划子课题、教育部博士点专项重点项目上海市自然科学基金上海市教委重点项目上海市卫计委中医药发展三年行动计划课题10余项,并承担企业合作横向课题10项。


学术任职


兼任中国中西医结合学会临床药理与毒理专业委员会委员、上海市药学会药理学专业委员会委员上海市中西医结合学会神经内分泌专业委员会委员、上海市免疫学会中医药免疫专委会委员、《中药药理与临床》杂志编委

课题组成员