• 李林楠
    副研究员
    研究方向:中药复杂体系分离分析新技术、新方法及应用研究
    邮箱:linnanli@shutcm.edu.cn
    职务:硕士生导师
    电话:021-51322506
    学历学位:博士

个人简历

教育背景

   

2013.09-2018.07    北京大学       理学博士


2009.09-2013.07    四川大学        理学学士

工作经历

   

2021.01至今      上海中医药大学中药研究所 副研究员


2020.07–2020.12   上海中医药大学中药研究所 助理研究员


2018.07–2020.07   上海中医药大学中药研究所 博士后


研究兴趣

中药功效成分发现和表征方法开发,质谱、色谱分析技术和应用,新型样品前处理介质,绿色化学策略,中药质量评价,代谢组学等。聚焦中药复杂体系的精准辨析,为中药药效物质基础研究、中药制剂与质量控制研究奠定基础。


个人荣誉

   

 上海市晨光学者、扬帆学者,上海市“超级博士后”,北京大学优秀毕业生



代表性论文

    

1. Ying Yang, Linnan Li*, Na Li, Fan Li, Wenxiang Fan, Yitian He, Zhengtao Wang*, Li Yang*, Rapid analysis of differential chemical compositions of Poria cocos using thin-layer chromatography spray ionization-mass spectrometry, Analyst, 2022, 147, 3072–3080


2. Yujia Tu, Linnan Li*, Wenxiang Fan, Longchan Liu, Zhengtao Wang, Li Yang*, Development of green and efficient extraction of bioactive ginsenosides from Panax ginseng with deep eutectic solvents, Molecules, 2022, 27, 4339


3. Yu Wang, Zhengcai Ju, Linnan Li, Ting Zhang, Siyu Zhang, Lili Ding, Changsen Zhan, Zhengtao Wang, Li Yang*, A complementary chromatographic strategy for integrated components characterization of Imperatae Rhizoma based on convergence and liquid chromatography combined with mass spectrometry and molecular network, Journal of Chromatography A, 2022, 1678, 463342


4. Wenxiang Fan, Yuangui Yang, Linnan Li, Linhong Fan, Zhengtao Wang*, Li Yang*, Mass spectrometry-based profiling and imaging strategy, a fit-for-purpose tool for unveiling the transformations of ginsenosides in Panax notoginseng during processing, Phytomedicine, 2022, 103, 154223


5. Yixin Zhang, Jiaojiao Wei, Linnan Li, Yamin Liu, Shuai Sun, Lu Xu, Shaoyong Liu, Zhengtao Wang, Li Yang*, Rapid identification of bear bile powder from other bile sources using chip-based nano-electrospray ionization tandem mass spectrometry, Rapid Communications in Mass Spectrometry, 2022, 36, e9326


6. Xing Yan, Linnan Li, Pei Liu, Jie Xu, Zhengtao Wang, Lili Ding*, Li Yang*, Targeted metabolomics profiles serum fatty acids by HFD induced non-alcoholic fatty liver in mice based on GC-MS, Journal of Pharmaceutical and Biomedical Analysis, 2022, 211, 114620


7. Fei Yang, Mooseob Kim, Lihua Gu*, Linnan Li, Li Yang, Zhengtao Wang*, Stimulation quantification of four natural lipase inhibitors from Alismatis Rhizoma by high-performance thin-layer chromatography method, JPC–Journal of Planar Chromatography–Modern TLC, 2022, 35, 3–12


8. Yilin Chen, Linnan Li*, Rui Xu, Fan Li, Lihua Gu, Huwei Liu, Zhengtao Wang, Li Yang*, Characterization of natural herbal medicines by thin-layer chromatography combined with laser ablation-assisted direct analysis in real-time mass spectrometry, Journal of Chromatography A, 2021, 1654, 462461


9. Yilin Chen, Linnan Li*, Fen Xiong, Yanqiao Xie, Aizhen Xiong, Zhengtao Wang, Li Yang*, Rapid identification and determination of pyrrolizidine alkaloids in herbal and food samples via direct analysis in real-time mass spectrometry, Food Chemistry, 2021, 334, 127472


10. Linnan Li#, Yamin Liu#, Zhengtao Wang, Li Yang*, Huwei Liu*, Development and applications of deep eutectic solvents derived functional materials in chromatographic separation, Journal of Separation Science, 2021, 44, 1098–1121


11. Yujia Tu, Linnan Li, Zhengtao Wang, Li Yang*, Advances in analytical techniques and quality control of traditional Chinese medicine injections, Journal of Pharmaceutical and Biomedical Analysis, 2021, 206, 114353


12. Linnan Li, Yilin Chen, Li Yang, Zhengtao Wang*, Huwei Liu*, Recent advances in applications of metal–organic frameworks for sample preparation in pharmaceutical analysis, Coordination Chemistry Reviews, 2020, 411, 213235


13. Linnan Li, Yilin Chen, Yuangui Yang, Ying Yang, Li Yang*, Zhengtao Wang*, Rapid and sensitive analysis of progesterone by solid-phase extraction with amino-functionalized metal-organic frameworks coupled to direct analysis in real-time mass spectrometry, Analytical and Bioanalytical Chemistry, 2020, 412, 2939–2947


14. Ruirong Zheng, Linnan Li, Xueli Deng, Mei Tian, Zhengtao Wang*, Li Yang*, Fully automated chip-based nanoelectrospray ionization-mass spectrometry as an effective tool for rapid and high-throughput screening of 5α-reductase inhibitors. Analytical and Bioanalytical Chemistry, 2020, 412, 1685–1692


15. Yanqiao Xie, Linnan Li, Yilin Chen, Yuangui Yang, Hong Xu*, Zhengtao Wang, Li Yang*, Rapid authentication of the agarwood by using liquid extraction surface analysis-mass spectrometry (LESA-MS), Phytochemical Analysis, 2020, 31, 801–808


16. Mei Tian, Linnan Li, Ruirong Zheng, Li Yang, Zhengtao Wang*, Advances on hormone-like activity of Panax ginseng and ginsenosides, Chinese Journal of Natural Medicines, 2020, 18, 1–10


授权专利


科研项目

主持国家自然科学基金,上海市“晨光计划”、“扬帆计划”等国家级和省部级项目6项。



学术任职

兼任上海市药学会药物分析专业委员会青年委员,中国化学会、中华中医药学会、中国仪器仪表学会、上海市药学会和上海市植物学会会员,Anal. Chem., J. Food Drug Anal., Analyst, Anal. Bioanal. Chem., J. Sep. Sci., Pharmaceuticals, Nanomaterials, Molecules等期刊审稿人,“十四五”本科规划教材《中药分析学》编委等。