中药抗肿瘤药理。主要针对中药/复方尤其是黄酮类成分抗肿瘤细胞/免疫细胞代谢重编程作用及机制研究。

1. Yu Mingzhu, Pan Qiaoling, Li Wenbiao, Du Tingting, Huang Fei, Wu Hui, He Yixin, Wu Xiaojun*, Shi Hailian*. Isoliquiritigenin inhibits gastric cancer growth through suppressing GLUT4 mediated glucose uptake and inducing PDHK1/PGC-1α mediated energy metabolic collapse. Phytomedicine, 2023, 121: 155045.

2. Gai Xiao, Qian Peng, Guo Benqiong, Zheng Yixin, Fu Zhihao, Yang Decai, Zhu Chunmei, Cao Yang, Niu Jingbin, Ling Jianghong, Zhao Jin*, Shi Hailian*, Liu Guoping*. Heptadecanoic acid and pentadecanoic acid crosstalk with fecal-derived gut microbiota are potential non-invasive biomarkers for chronic atrophic gastritis. Frontiers in Cellular and Infection Microbiology, 2023, 12: 1064737.

3. Wang Ping#, Jin Jinmei#, Liang Xiaohui, Yu Mingzhu, Yang Chun, Huang Fei, Wu Hui, Zhang Beibei, Fei Xiaoyan, Wang Zhengtao, Xu Ren, Shi Hailian*, Wu Xiaojun*. Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming. Acta Pharmacologica Sinica, 2022, 43, 1581-1593.

4. Liang Xiaohui, Wang Ping, Yang Chun, Huang Fei, Wu Hui, Shi Hailian*, Wu Xiaojun*. Galangin inhibits gastric cancer growth through enhancing STAT3 mediated ROS production. Frontiers in Pharmacology, 2021, 12: 646628.

5. Wang Zhiying, Liang Xiaohui, Xiong Aizheng, Ding Lili, Li Wei, Yang Li, Wu Xiaojun, Shi Hailian*, Zhou Yue*, Wang Zhengtao. Helichrysetin and TNF-α synergistically promote apoptosis by inhibiting overactivation of the NF-κB and EGFR signaling pathways in HeLa and T98G cells. International Journal of Molecular Medicine, 2021, 47(4): 49. 

6. Yin Jing#, Yi Jinyu#, Yang Chun, Xu Bo, Lin Jiang, Hu Hongyi, Wu Xiaojun, Shi Hailian*, Fei Xiaoyan*. Chronic atrophic gastritis and intestinal metaplasia induced by highsalt and NmethylN'nitroNnitrosoguanidine intake in rats. Experimental & Therapeutic Medicine, 2021, 21(4): 315.

7. 余明珠，潘巧岭，李文标，杜婷婷，吴辉，黄菲，吴晓俊，石海莲. 参芪健胃颗粒调节能量代谢重编程抑制胃癌作用及机制. 中药药理与临床. 2023. DOI:10.13412/j.cnki.zyyl.20230815.008

8. 余明珠,石海莲,吴晓俊. 神经系统影响非神经系统肿瘤发生发展的研究进展. 中国药理学与毒理学杂志. 2022. 36(12): 936-943.

9. 梁晓晖, 石海莲*, 吴晓俊*. 糖代谢重编程与“炎-癌转化”及抗炎中药靶向肿瘤糖代谢抗肿瘤作用机制研究进展. 中国药理学与毒理学杂志, 2021;35(11): 859-867.

10. 梁晓晖, 余明珠, 石海莲*, 吴晓俊*. 高良姜素抑制胃癌MGC803细胞NF-kB通路促进自噬. 中国中药杂志. 2021; 46(16): 4167-4174.

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先后主持国家自然科学基金、上海市自然科学基金等7项，并承担企业合作横向课题5项，另参与国家自然科学基金、教育部博士点专项优先发展领域项目等10余项。