教育背景

2002.12－2004.12    上海中医药大学   博士后

1999.09－2002.07    新疆医科大学     理学博士

1995.09－1998.07    新疆医科大学     理学硕士

1982.09－1986.07    新疆医学院        理学学士

工作经历

2005.01-今        上海中医药大学中药研究所 研究员，博士生导师

2013.09–2014.09   美国密西根大学药学院高级访问学者

2002.12–2004.12   上海中医药大学中药研究所 博士后

1998.09–2002.12   新疆医科大学第二附属医院药剂科 副教授，副主任药师

1992.09–1998.09   新疆医科大学第二附属医院药剂科 主管药师

1986.09–1992.09   新疆医科大学第二附属医院药剂科 药师

1986.09–1987.08   新疆克孜勒苏自治州阿合奇县一中 支教

1981.09–1982.08   新疆生产建设兵团第十师独立营中学 教师

针对中药活性成分的吸收、体内外代谢特征、代谢减毒增效机制研究，为中药药效物质基础研究、中药新制剂与质量控制研究奠定基础。

个人荣誉

 2013年度上海市优秀学术带头人计划

获奖情况

教育部自然科学奖一等奖2项（2015，名列第4位；2011，名列第3位）

上海市科技进步一等奖（2009，名列第15位）

江西省自然科学二等奖（2019，名列第2位）

新疆维吾尔自治区科技进步二等奖2项(2018，名列第2位；2002，名列第2位)

新疆维吾尔自治区科技进步三等奖（2003，名列第3位）

新疆生产建设兵团科技进步三等奖 (2006，名列第3位)。

乌鲁木齐市科技进步三等奖 (2005，名列第3位)

1. Wang Yaru and Wang Changhong*. Novel Eye Drop Delivery Systems: Advance on Formulation Design Strategies Targeting Anterior and Posterior Segments of the Eye. Pharmaceutics, 2022, 14, 1150.

2. Xie Qi, Wang Changhong*. Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014–2021). Phytochemistry, 2022, 201: 113288.

3. Zhang Congcong#, Zhang Dingqi#, Wang Yongli, Zhang Linzhang, Qi Shenglan, Fang Qinqin, Xu Ying, Chen Jiamei, Cheng Xuemei, Liu Ping*, Wang Changhong*, Liu Wei*. Pharmacokinetics and anti-liver fibrosis characteristics of amygdalin: Key role of the deglycosylated metabolite prunasin. Phytomedicine, 2022, 99: 154018.

4. Cao Ning, Li Shuping, Xu Aimin, Li Manlin, Zou Xiaoguang, Ke Zunji, Deng Gang, Cheng Xuemei, Wang Changhong*. Dynamic changes of endogenic or exogenic β-carboline alkaloid harmine in different mammals and human in vivo at developmental and physiological states. Frontiers in Aging Neuroscience, 2022, 10.3389/fnagi.2021.773638

5. Wang Youxu#, Cao Ning#, Guan Huida, Cheng Xuemei, Wang Changhong*. Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine. Chinese Journal of Natural Medicines, 2022, 20(3): 194-20. 

6. Xie Qi, Tian Hemiao, Huan Xiaohan, Cao Lanlan, Wang Yan, Cheng Xuemei, Ning Chuguang, Hu Fangdi, Wang Changhong*. Quality evaluation of Codonopsis Radix and processed products based on the analysis of monosaccharides and oligosaccharides by liquid chromatography coupled with charged aerosol detector. Phytochemical Analysis. 2022; 33:262-271.

7. Guan Huida, Lin Qiyan, Ma Chao, Ju Zhengcai, Wang Changhong*. Metabolic Profiling and Pharmacokinetic Studies of Sinapine thiocyanate by UHPLC-Q/TOF-MS and UHPLC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 2021, 207: 114431.

8. Xie Zhejun, Cao Ning, Wang Changhong*. A review on β-carboline alkaloids and their distribution in foodstuffs: A class of potential functional components or not? Food Chemistry, 2021, 348: 129067

9. Li Manlin, Wang Hanxue, Huan Xiaohan, Cao Ning, Guan Huida, Zhang Hongmei, Cheng Xuemei, Wang Changhong*. Simultaneous LC-MS/MS bioanalysis of alkaloids, terpenoids, and flavonoids in rat plasma through salting-out-assisted liquid-liquid extraction after oral administration of extract from Tetradium ruticarpum and Glycyrrhiza uralensis: a sample preparation strategy to broaden analyte coverage of herbal medicines. Analytical and Bioanalytical Chemistry, 2021, 413(23), 5871-5884.

10. Cao Ning, Wang Changhong*. Strictosidine synthase, an indispensable enzyme involved in the biosynthesis of terpenoid indole and β-carboline alkaloids. Chinese Journal of Natural Medicines 2021, 19(8): 591-607 

11. Liu Hanze, Wang Changhong*. The genus Asarum: A review on phytochemistry, ethnopharmacology, toxicology and pharmacokinetics. Journal of Ethnopharmacology, 2022, 282,114642.

12. Lin Qiyan, Guan Huida, Ma Chao, Chen Liangni, Cao Lanlan, Liu Hanze, Cheng Xuemei, Wang Changhong*. Biotransformation patterns of dictamnine in vitro/in vivo and its relative molecular mechanism of dictamnine-induced acute liver injury in mice. Environmental Toxicology and Pharmacology, 2021, 85: 103628 

13. Huang Guiting, Xie Jin, Shuai Shuyuan, Wei Shaofeng, Chen Yingchong, Guan Zhiyu, Zheng Qin, Yue Pengfei*, Wang Changhong*. Nose-to-brain delivery of drug nanocrystals by using Ca2+ responsive deacetylated gellan gum based in situ-nanogel. International Journal of Pharmaceutics, 2021, 594:120182

14. Kwong Sukfan P., Huang Zhenlin, Ji Lili*, Wang Changhong*. PORIMIN: The key to (+)-Usnic acid-induced liver toxicity and oncotic cell death in normal human L02 liver cells. Journal of Ethnopharmacology, 2021, 270: 113873

15. Ma Chao, Guan Huida, Lin Qiyan, Liu Chang, Ju Zhengcai, Xue Yafu, Cheng Xuemei, Wang Changhong*. Dynamic changes in chemical compositions and anti-acetylcholinesterase activity associated with steaming process of stem-leaf saponins of Panax notoginseng. Biomedical Chromatography. 2021, e5077 

16. Ma Chao, Lin Qiyan, Xue Yafu, Ju Zhengcai, Deng Gang, Liu Wei, Sun Yuting, Guan Huida, Cheng Xuemei, Wang Changhong*. Pharmacokinetic studies of ginsenosides Rk1 and Rg5 in rats by UFLC–MS/MS. Biomedical Chromatography. 2021, e5108

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2. 王长虹，刘伟，程雪梅，戚胜兰. 王浆酸在制备治疗腺苷脱氨酶活性升高的疾病药中的用途. ZL201810030247.6

3. 王长虹，王峥涛，程雪梅，刘伟，温方方. 一种由骆驼蓬草制备骆驼蓬草总生物碱提取物和骆驼蓬草总黄酮提取物的方法。ZL 201410582024.2

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5. 王长虹，王峥涛，程雪梅，温方方. 一种分析骆驼蓬草中有效成分的方法. ZL201210148859.8

6. 王长虹，王峥涛，程雪梅，杨涛，盛欢欢. 一种穿心莲内酯的应用. ZL201110194819.2

先后主持科技部国家重点研发计划子课题、科技部重大新药专项子课题、国家自然基金重点项目、国家自然基金面上项目、上海市中药现代化专项、上海市科委基础研究重点项目、上海市纳米专项、上海市国内合作计划、上海市教育委员会科研创新重点项目等30余项，并承担企业合作横向课题10余项。

兼任世界中联中药药剂专业委员会第三届理事会常务理事、上海市药学会药剂专业委员会委员、上海市药学会药事管理专委会委员、中国实验方剂学杂志常务编委、国际药学研究杂志、中成药、中国药师等杂志编委等。