围绕中药效应物质与质量评价研究的关键科学问题，基于临床应用及靶标表征鉴定中药效应物质，构建以功效成分为核心指标的科学、先进、适用的质量评价体系，并实现基础研究成果高效转化，应用于国际、国家、行业及地方质量标准的制订和提升。

个人荣誉

2022年度上海市中医药高层次人才引领计划

2022年度中华中医药学会中青年创新人才

2020年度国家中医药管理局青年岐黄学者

2017年度上海市“优秀学术带头人”

2012年度国家自然科学基金委员会“优秀青年基金”

2012年度教育部“新世纪人才”

获奖情况

上海市科技进步一等奖（2023，名列第3位）

上海药学科技奖（基础研究类）二等奖（2017，名列第1位）

      教育部自然科学奖一等奖3项（2015，名列第8位；2011，名列第6位；2008，名列第3位）

国家科学技术进步奖二等奖（2010，名列第8位）

1. Liu Longchan, Wang Ziying, Zhang Qian, Mei Yuqi, Li Linnan*, Liu Huwei, Wang Zhengtao, Yang Li*; Ion Mobility Mass Spectrometry for the Separation and Characterization of Small Molecules, Analytical Chemistry, 2023, 95(1): 134-151.

2. Zhang Eryun; Jin Lihua; Wang Yangmeng; Tu Jui; Zheng Ruirong; Ding Lili; Fang Zhipeng; Fan Mingjie; Ismail Al-Abdullah; Rama Natarajan; Ma Ke; Wang Zhengtao; Arthur Riggs; Sarah C. Shuck; Yang Li*; Huang Wendong*; Intestinal AMPK modulation of microbiota mediates cross-talk with brown fat to control thermogenesis. Nature Communications. 2022, 13(1): 1135.

3. Fan Linhong; Fan Wenxiang; Mei Yuqi; Liu Longchan; Li Linnan; Wang Zhengtao*; Yang Li*. Mechanochemical assisted extraction as a green approach in preparation of bioactive components extraction from natural products - A review. Trends in Food Science & Technology, 2022, 129: 98-110.

4. Zhang Jiwei*; Li Shengli; Zhang Jianian; Zhang Wen; Jiang Jiawen; Wu Hao; Wu Enjiang; Feng Yutao; Yang Li*; Li Zhe*, Docetaxel resistance-derived LINC01085 contributes to the immunotherapy of hormone-independent prostate cancer by activating the STING/MAVS signaling pathway. Cancer Letters, 2022, 545: 215829.

5. Chen Yilin; Xie Yanqiao; Li Linnan; Wang Zhengtao; Yang Li, Advances in mass spectrometry imaging for toxicological analysis and safety evaluation of pharmaceuticals. Mass Spectrometry Reviews, 2022, e21807.

6. Wang Weiqian; Chen Yan; Yin Yue; Wang Xunjiang; Ye Xuanling; Jiang Kaiyuan; Zhang Yi; Zhang Jiwei; Zhang Wei; Zhuge Yuzheng; Chen Li; Peng Chao; Xiong Aizhen; Yang Li*; Wang Zhengtao*, A TMT-based shotgun proteomics uncovers overexpression of thrombospondin 1 as a contributor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome, Archives of Toxicology, 2022, 12(7): 2003-2019.

7. Ding Lili; Yang Qiaoling; Zhang Eryun; Wang Yangmeng; Sun Siming; Yang Yingbo; Tian Tong; Ju Zhengcai; Jiang Linshan; Wang Xunjiang; Wang Zhengtao; Huang Wendong*; Yang Li*; Notoginsenoside Ft1 acts as a Tgr5 agonist but Fxr antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice, Acta Pharmaceutica Sinica B. 2021, 11(6):1541-1554.

8. Ding Lili; Zhang Eryun; Yang Qiaoling; Jin Lihua; Kyle M. Sousa; Dong Bingning; Wang Yangmeng; Tu Jui; Ma Xiaoxiao; Tian Jingyan; Zhang Hongli; Fang Zhipeng; Guan Ana; Zhang Yixin; Wang Zhengtao; David D. Moore*; Yang Li*; Huang Wendong*; Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice, Proceedings of the National Academy of the Sciences of the United States of America, 2021, 118(6): e2019388118.

9. Chen Yilin; Li Linnan*; Xiong Fen; Xie Yanqiao; Xiong Aizhen; Wang Zhengtao; Yang Li*; Rapid identification and determination of pyrrolizidine alkaloids in herbal and food samples via direct analysis in real-time mass spectrometry, Food Chemistry, 2021, 334: 127472.

10. Yu Shenglan; Jiang Jiarui; Li Qinqin; Liu Xuan; Wang Zhengtao; Yang Li*; Ding Lili*, Schisantherin A alleviates non-alcoholic fatty liver disease by restoring intestinal barrier function. Frontiers in Cellular and infection Microbiology, 2022,12: 855008.

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先后主持科技部国家十二五、十三五“重大新药创制”科技专项、国家自然科学基金优秀青年基金、国家自然科学基金面上项目、上海市科委优秀学术带头人项目、上海市科委技术标准专项等国家及省部级课题10余项，并承担企业合作横向课题3项。

   兼任国家药监局第十二届药典委员会委员、中药标准化技术国家工程研究中心副主任、上海市药学会药物分析专业委员会副主任委员等。