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1.Ding LL, Sousa KM, Jin LH, Dong BN, Kim BW, Ramirez R, Xiao ZZ, Gu Y, Yang QL, Wang J, Yu D, Pigazzi A, Schones D, Yang L, Moore D, Wang ZT*, Huang WD*. Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice. Hepatology. 2016, 64:760-773. Impact Factor:11.711

2.Pang C#, Zheng ZY#, Shi L, Sheng YC, Wei H, Wang ZT, Ji LL*. Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system. Free Radical Biology and Medicine 2016, 91:236-246. (5.784)

3.Liu HS#, Shi HL#, Huang F, Peterson KE, Wu H, Lan YY, Zhang BB, He YX, Woods T, Du M*, Wu XJ*, Wang ZT. Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway. Sci Rep. 2016, 6:19137. (5.228)

4.Wu H#, Gao Y#, Shi HL, Qin LY, Huang F, Lan YY, Zhang BB, Hu ZB*, Wu XJ*. Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network. Sci Rep. 2016, 6:30190. (5.228)

5.Yang F#, Tang XW#, Ding LL, Zhou Y, Yang QL, Gong JT, Wang GY, Wang ZT*, Yang L*. Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation. Sci Rep. 2016, 6: 33052. (5.228)

6.Yu ZY#, Zhang TY#, Gong CY, Sheng YC, Lu B, Zhou LY, Ji LL*, Wang ZT. Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway. Sci Rep. 2016, 6: 34306. (5.228)

7.Yang F, Gong JT, Wang GY, Chen P, Yang L*, Wang ZT*. Waltonitone inhibits proliferation of hepatoma cells and tumorigenesis via FXR-miR-22-CCNA2 signaling pathway. Oncotarget. 2016, 7:75165. (5.008)

8.Zhang J*, Chou GX*, Liu ZJ, Liu M. Employing rubusoside to improve the solubility and permeability of antitumor compound betulonic acid. Nanomedicine. 2016, 11:2829-2844. (4.889)

9.Yan J, Shi SS, Wang HW, Liu RM, Li N, Chen YL, Wang SC*. Neutral monosaccharide composition analysis of plant-derived oligo- and polysaccharides by high performance liquid chromatography. Carbohydrate Polymers. 2016, 136:1273-1280. (4.219)

10.Wu JJ, Shi SS, Wang HJ, Wang SC*. Mechanisms underlying the effect of polysaccharides in the treatment of type 2 diabetes: A review. Carbohydrate Polymers. 2016, 144:474-494. (4.219

11.Chen MM#, Wu JJ#, Shi SS, Chen YL, Wang HJ, Fan HW, Wang SC*. Structure analysis of a heteropolysaccharide from Taraxacum mongolicum Hand.-Mazz. and anticomplementary activity of its sulfated derivatives . Carbohydrate Polymers. 2016, 152: 241-252. (4.219)

12.Liu MY, Hong C, Yao YS, Shen HY, Ji G, Li GW*, Xie Y*. Development of a pharmaceutical cocrystal with solution crystallization technology: Preparation, characterization, and evaluation of myricetin-proline cocrystals. Eur J Pharm Biopharm. 2016, 107:151-159. (3.975)

13.Sun AN, Ren GY, Deng C, Zhang JL, Luo XP, Wu XJ, Mani S, Dou W*, Wang ZT*. C-glycosyl flavonoid orientin improves chemically induced inflammatory bowel disease in mice. Journal of Functional Foods. 2016, 21:418-430. (3.973)

14.Ding LL, Li JM, Song BL, Xiao X, Zhang BF, Qi M, Huang WD, Yang L*, Wang ZT*. Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway. Toxicol Appl Pharmacol. 2016, 304:99-109. (3.847)

15.Zhao SM, Chou GX*, Yang QS, Wang W, Zhou JL. Abietane diterpenoids from Caryopteris incana (Thunb.) Miq. Organic and Biomolecular Chemistry. 2016, 14:3510-3520. (3.559)

16.Chen YL, Shi SS, Wang HJ, Li N, Su J, Chou GX*, Wang SC*. A homogeneous polysaccharide from fructus Schisandra chinensis (Turz.) baill induces mitochondrial apoptosis through the Hsp90/AKT signalling pathway in HepG2 Cells. International Journal of Molecular Sciences. 2016, 17:1015. (3.257)

17.Yang YD#, Cheng XM#, Liu W, Han ZZ, Chou GX, Wang Y, Sun DX, Wang ZT, Wang CH*. Peganumine B-I and two enantiomers: new alkaloids from the seeds of Peganum harmala Linn. and their potential cytotoxicity and cholinesterase inhibitory activities. RSC Adv. 2016, 6: 15976-15987. (3.289)

18.Yang QL, Yang F, Gong JT, Tang XW, Wang GY, Wang ZT, Yang L*. Sweroside ameliorates α-naphthylisothiocyanate-induced cholestatic liver injury in mice by regulating bile acids and suppressing pro-inflammatory responses. Acta Pharmacologica Sinica. 2016, 37: 1218-1228. (3.166)

19.Lv XC#, Chen DD#, Yang LC, Zhu N, Li JL, Zhao J, Hu ZB, Wang FJ*, Zhang LS*. Comparative studies on the immunoregulatory effects of three polysaccharides using high content imaging system. International Journal of Biological Macromolecules. 2016, 86:28-42. (3.138)

20.Wu YJ#, Li S#, Li HX, Zhao CZ, Ma H, Zhao XN, Wu JH, Liu KL, Shan JJ*, Wang YX*. Effect of a polysaccharide from Poria cocos on humoral response in mice immunized by H1N1 influenza and HBsAg vaccines. Int J Biol Macromol. 2016, 91:248-257. (3.138)

21.He M, Wang HY, Dou W, Chou GX, Wei XH*, Wang ZT. Preparation and drug release properties of norisoboldine-loaded chitosan microspheres. Int J Biol Macromol. 2016, 91:1101-1109. ( 3.138)

22.Zhu N, Lv XC, Wang YY, Li JL, Liu YM, Lu WF, Yang LC, Zhao J, Wang FJ*, Zhang LS*. Comparison of immunoregulatory effects of polysaccharides from three natural herbs and cellular uptake in dendritic cells. Int J Biol Macromol. 2016, 93:940-951. ( 3.138)

23.Zhou LY, Zhang TY, Lu B, Yu ZY, Mei XY, Abulizi P, Ji LL*. Lonicerae Japonicae Flos attenuates diabetic retinopathy by inhibiting retinal angiogenesis. J Ethnopharmacol. 2016, 189: 117-125. (3.055)

24.Tang XW, Yang QL, Yang F, Gong JT, Han H, Yang L*, Wang ZT. Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice. J Ethnopharmacol. 2016, 194: 63-71. (3.055)

25.Xiong AZ, Yan AL, Bi CWC, Lam KYC, Chan GKL, Lau KKM, Dong TTX, Lin HQ, Yang L, Wang ZT, Tsim KWK*. Clivorine, an otonecine pyrrolizidine alkaloid from Ligularia species, impairs neuronal differentiation via NGF-induced signaling pathway in cultured PC12 cells. Phytomedicine. 2016, 23:931-938. (2.937)

26.Wang DD, Qi M, Yang QM, Tong RC, Wang R, Bligh SWA, Yang L*, Wang ZT. Comprehensive metabolite profiling of Plantaginis Semen using ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry coupled with elevated energy technique. J Sep Sci. 2016, 39:1842-1852. (2.741)

27.Li JM#, Ding LL#, Song BL, Xiao X, Qi M, Yang QL, Yang QM, Tang XW, Wang ZT, Yang L*. Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway. Eur J Pharmacol. 2016,770:99-109. (2.73)

28.Pang C#, Shi L#, Sheng YC*, Zheng ZY, Wei H, Wang ZT, Ji LL*. Caffeic acid attenuated acetaminophen-induced hepatotoxicity by inhibiting ERK1/2-mediated early growth response-1 transcriptional activation. Chemico-Biological Interactions. 2016, 260:186-195. (IF2.618)

29.Yang N, Xiong AZ, Wang R*, Yang L*, Wang ZT. Quality evaluation of traditional Chinese medicine compounds in Xiaoyan Lidan Tablets: fingerprint and quantitative analysis using UPLC-MS. Molecules. 2016, 21:83. (2.465)

30.Zhao H, Peng QH, Han ZZ*, Yang L*, Wang ZT. Three new sesquiterpenoids and one new sesquiterpenoid derivative from Chinese eaglewood. Molecules. 2016,21:281. (2.465)

31.Zhan CS, Xiong AZ, Shen DP, Yang L*, Wang ZT*. Characterization of the principal constituents of Danning Tablets, a Chinese formula consisting of seven herbs, by an UPLC-DAD-MS/MS approach. Molecules. 2016, 21: 631. (2.465)

32.Li XJ#, Bao WR#, Leung CH, Ma DL, Zhang G, Lu AP, Wang SC*, Han QB*. Chemical structure and immunomodulating activities of an α-Glucan purified from Lobelia chinensis Lour. Molecules. 2016, 21:779-795. (2.465)

33.Tang JH#, Zhou JG#, Tang QJ, Wu T*, Cheng ZH*. A new TLC bioautographic assay for qualitative and quantitative estimation of lipase inhibitors. Phytochemical Analysis. 2016, 27:5-12. (2.341)

34.Lu B, Sheng YC, Zhang JQ, Zheng ZY, Ji LL*. The altered microRNA profile in andrographolide-induced inhibition of hepatoma tumor growth. Gene. 2016, 588:124-133. (2.319)

35.Zheng ZY, Shi L, Sheng YC, Zhang JQ, Lu B, Ji LL*. Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: the potential contribution of NFκB, Egr1, Nrf2, MPAKs and PI3K signals. Environmental Toxicology and Pharmacology. 2016, 46:80-89. (2.084)

36.Cheng JJ, Ma TY, Liu W, Wang HX, Jiang JZ, Wei Y, Tian HM, Zou N, Zhu YD, Shi HL, Cheng XM*, Wang CH*. In in vivo evaluation of the anti-inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models. BMC Complementary and Alternative Medicine. 2016, 16:20. (1.987)

37.Li HL, Wu H, Zhang BB, Shi HL, Wu XJ*. MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC803 cell proliferation and IL-8 secretion in vitro and in vivo. Mol Med Rep. 2016, 14:1430-1438 . (1.559)

38.Li SP, Teng L, Liu W, Cheng XM, Jiang B, Wang ZT, Wang CH*. Pharmacokinetic study of harmane and its 10 metabolites in rat after intravenous and oral administration by UPLC-ESI-MS/MS. Pharm Biol. 2016, 54:1768-1781. (1.546)

39.Niu CW, Sheng YC, Zhu EY, Ji LL*, Wang ZT. Ferulic acid prevents liver injury induced by Diosbulbin B and its mechanism. BioScience Trends. 2016, 10:386-391. (1.533)

40.Xu JL, Gu LH, Wang ZT, Bligh A, Han ZZ*, Liu SJ*. Seventeen steroids from the pith of Tetrapanax papyriferus. Journal of Asian Natural Products Research. 2016, 18:1131-1137. (1.009)

41.Gong CY, Lu B, Sheng YC, Yu ZY, Zhou JY, Ji LL*. The development of diabetic retinopathy in Goto-Kakizaki rat and the expression of angiogenesis-related signals. Chinese Journal of Physiology. 2016, 59: 100-108. (0.962)


1.Yang X, Wang H, Ni HM, Xiong AZ, Wang ZT, Sesaki H, Ding WX*, Yang L*. Inhibition of Drp1 protects against senecionine-induced mitochondriamediated apoptosis in primary hepatocytes and in mice. Redox Biology. 2017, 12:264-273. (Impact Factor: 6.337)

2.Zhang EY, Gao B, Shi HL, Huang LF, Yang L, Wu XJ*, Wang ZT*. 20(S)-Protopanaxadiol enhances angiogenesis via HIF-1α-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice. Experimental and Molecular Medicine. 2017, 49:e387. (5.036)

3.Zhang L#, Shi JY#, Tang JH, Cheng ZH*, Lu XH, Kong Y, Wu T*. Direct coupling of thin-layer chromatography-bioautography with electrostatic field induced spray ionization-mass spectrometry for separation and identification of lipase inhibitors in lotus leaves. Analytica Chimica Acta. 2017, 967:52-58. (4.95)

4.Wu JJ, Chen MM, Shi SS, Wang HJ, Li N, Su J, Liu RM, Huang ZL, Jin H. Ji XQ*. Wang SC*. Hypoglycemic effect and mechanism of a pectic polysaccharide with hexenuronic acid from the fruits of Ficus pumila L. in C57BL/KsJ db/db mice. Carbohydrate Polymers. 2017, 178:209-220. (4.811)

5.Li SP, Zhang YP, Deng G, Wang YW, Qi SL, Cheng XM, Ma YM, Xie Y, Wang CH*. Exposure characteristics of the analogous β-carboline alkaloids harmaline and harmine based on the efflux transporter of multidrug resistance protein 2. Frontiers in Pharmacology. 2017, 8:541. (4.4)

6.Li HL#, Lu L#, Wang XS, Qin LY, Wang P, Qiu SP, Wu H, Huang F, Zhang BB, Shi HL*, Wu XJ*. Alteration of gut microbiota and inflammatory cytokine/chemokine profiles in 5-fluorouracil induced intestinal mucositis. Frontiers in Cellular and Infection Microbiology. 2017, 7:455. (4.3)

7.Luo XP#, Yu Z#, Deng C, Zhang JJ, Ren GY, Sun AN, Mani S, Wang ZT*, Dou W*. Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice. Scientific Reports. 2017, 7:16374. (4.259)

8.Xu SF, Liu J, Shi JS, Wang ZT, Ji LL*. 2,3,4’,5-Tetrahydroxystilbene-2-O-β-D- glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2. Scientific Reports. 2017, 7:16511. (4.259)

9.Sun QH, Zhang Y, Chou GX*. Synthesis and anti-obesity effects in vivo of Crotadihydrofuran C as a novel PPARγ antagonist from Crotalaria albida. Scientific Reports. 2017, 7:46735. (4.259)

10.Wang RF, Li J, Hu HJ, Li J, Yang YB, Yang L, Wang ZT*. Chemical transformation and target preparation of saponins in stems and leaves of Panax notoginseng. Journal of Ginseng Research. 10.1016/j.jgr.2016.08.009. (4.082)

11.Wei MJ, Zheng ZY, Shi L, Jin Y, Ji LL*. Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity by activating ERK/Nrf2 antioxidative pathway. Toxicological Sciences. 2017, kfx230:1-14. (4.081)

12.Cao Q#, Qin LY#, Huang F*, Wang XS, Yang L, Shi HL, Wu H, Zhang BB, Chen ZY, Wu XJ*. Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through PI3K/Akt and ERK signaling pathways. Toxicology and Applied Pharmacology. 2017, 319:80-90. (3.791)

13.Huang ZL, Chen MW, Zhang JQ, Sheng YC, Ji LL*. Integrative analysis of hepatic microRNA and mRNA to identify potential biological pathways associated with monocrotaline-induced liver injury in mice. Toxicology and Applied Pharmacology. 2017, 333:35-42. (3.791)

14.Bai QY, Yan HY, Sheng YC, Jin Y, Shi L, Ji LL*, Wang ZT*. Long-term acetaminophen treatment induced liver fibrosis in mice and the involvement of Egr-1. Toxicology. 2017, 382:47-58. (3.582)

15.Zhang CG, Chou GX*, Mao,XD, Yang QS, Zhou JL. Nepetaefolins A-J, cytotoxic chinane and abietane diterpenoids from Caryopteris nepetaefolia. Journal of Natural Products. 2017, 80:1742-1749. (3.281)

16.Yang QM, Qi M, Tong RC, Wang DD, Ding LL, Li ZY, Huang C, Wang ZT*, Yang L*. Plantago asiatica L. seed extract improves lipid accumulation and hyperglycemia in high-fat diet-induced obese mice. International Journal of Molecular Sciences. 2017, 18:1393. (3.226)

17.Hu XR, Chou GX*, Zhang CG. Flavonoids, alkaloids from the seeds of Crotalaria pallida and their cytotoxicity and anti-inflammatory activities. Phytochemistry. 2017, 143:64-71. (3.205)

18.Li N, Shi CC, Shi SS, Wang HJ, Yan J, Wang SC*. An inulin-type fructan isolated from Artemisia japonica and its anti-arthritic effects. Journal of Functional Foods. 2017, 29:29-36. (3.144)

19.Shi L#, Zhang GQ#, Zheng ZY, Lu B, Ji LL*. Andrographolide reduced VEGFA expression in hepatoma cancer cells by inactivating HIF-1α: The involvement of JNK and MTA1/HDCA. Chemico-Biological Interactions. 2017, 273:228-236. (3.143)

20.Li SP, Cheng XM, Wang CH*. A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum. Journal of Ethnopharmacology. 2017, 203: 127–162 . (2.981)

21.Liu W#, Zhu YD#, Wang YL, Qi SL, Wang YW, Ma C, Li SP, Jiang B, Cheng XM, Wang ZT, Xuan ZY*, Wang CH*. Anti-amnesic effect of extract and alkaloid fraction from aerial parts of Peganum harmala on scopolamine-induced memory deficits in mice. Journal of Ethnopharmacology. 2017, 204:95-106. (2.981)

22.Wang XS#, Yang L#. Yang L, Xing FP, Yang H, Qin LY, Lan YY, Wu H, Zhang BB, Shi HL, Lu C, Huang F*, Wu XJ*, Wang ZT. Gypenoside IX suppresses p38 MAPK/Akt/NFkB signaling pathway activation and inflammatory respenses in astrocytes stimulated by proinflammatory mediators. Inflammation. 2017, 40:2137-2150. (2.955)

23.Zhang JQ, Sheng YC*, Shi L, Zheng ZY, Chen MW, Lu B, Ji LL*. Quercetin and baicalein suppress monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats. European Journal of Pharmacology. 2017, 795: 160-168. (2.896)

24.Zhang JX, Zhou LB, Zheng XY, Zhang JJ, Yang L, Tan RH, Zhao SJ*. Overexpression of SmMYB9b enhances tanshinone concentration in Salvia miltiorrhiza hairy roots. Plant Cell Reports. 2017, 36:1297-1309. (2.869)

25.Jiang JZ, Yang BH, Ji LL, Yang L, Mao YC, Hu ZH, Wang ZT, Wang CH*. Metabolic-induced cytotoxicity of diosbulbin B in CYP3A4-expressing cells. Toxicology in Vitro. 2017, 38:59-66. (2.866)

26.Mao XD, Chou GX*, Zhao SM, Zhang CG. New iridoid glucosides from Caryopteris incana (Thunb.) Miq. and their α-glucosidase inhibitory activities. Molecules. 2016, 21:1749. (2.861)

27.Shi J, Wang J, Yu L, Yang L, Zhao SJ*, Wang ZT*. Rapidly directional biotransformation of tauroursodeoxycholic acid through engineered Escherichia coli. Journal of Industrial Microbiology and Biotechnology. 2017, 44:1073-1082. (2.81)

28.Li SP, Teng L, Liu W, Cheng XM, Jiang B, Wang ZT, Wang CH*. Interspecies metabolic diversity of harmaline and harmine in in vitro 11 mammalian liver microsomes. Drug Testing and Analysis. 2017, 9:754-768. (2.74)

29.Zhang EY, Shi HL, Yang L, Wu XJ*, Wang ZT*. Ginsenoside Rd regulates the Akt/mTOR/p70S6K signaling cascade and suppresses angiogenesis and breast tumor growth. Oncology Reports. 2017, 38:359-367. (2.66)

30.Zhang YM, Chen ZY, Xu XK, Zhou Q, Liu XL, Liao LP, Zhang ZJ*, Wang ZT. Rapid separation and simultaneous quantitative determination of 13 constituents in Psoraleae Fructus by a single marker using high-performance liquid chromatography with diode array detection. Journal of Separation Science. 40: 4191-4202. (2.557)

31.Wang HW#, Li N#, Zhu C, Shi SS, Jin H, Wang SC*. Anti-complementary activity of two homogeneous polysaccharides from Eclipta prostrata. Biochemical and Biophysical Research Communications. 2017, 493:887-893. (2.466)

32.Liu HS, Huang F, Wu H, Zhang BB, Shi HL*, Wu XJ*, Hu ZB. Isoastragaloside I inhibits NF-κB activation and inflammatory responses in BV-2 microglial cells stimulated with lipopolysaccharide. International Journal of Molecular Medicine. 2017, 40:1270-1276. (2.341)

33.Zhou JG, Tang QJ, Wu T*, Cheng ZH*. Improved TLC bioautographic assay for qualitative and quantitative estimation of tyrosinase inhibitors in natural products. Phytochemical Analysis. 2017, 28:115-124. (2.292)

34.Zou N#, Wei Y#, Li FH, Yang Y, Cheng XM, Wang CH*. The inhibitory effects of compound Muniziqi granule against B16 cells and harmine induced autophagy and apoptosis by inhibiting Akt/mTOR pathway. BMC Complementary and Alternative Medicine. 2017, 17:517 (2.288)

35.Ye Z, Dai JR, Zhang CG, Lu Y, Wu LL, Gong AGW, Xu H*, Tsim KWK, Wang ZT. Chemical differentiation of Dendrobium officinale and Dendrobium devonianum by using HPLC fingerprints, HPLC-ESI-MS, and HPTLC analyses. Evidence-Based Complementary and Alternative Medicine.2017, 8647212. (1.74)

36.Liu Q, Wang SC*, Ding K*. Research advances in the treatment of Alzheimer's disease with polysaccharides from traditional chinese medicine. Chinese Journal of Natural Medicines. 2017, 15:641-652. (1.667)

37.Zhang CG#, Jin MR#, Chou GX*, Yang QS*. Plebeins A-F, sesquiterpenoids and diterpenoids from Salvia plebeian. Phytochemistry Letters. 2017, 19:254-258. (1.418)

38.Mei XY, Zhou LY, Zhang TY, Lu B, Ji LL*. Scutellaria barbata attenuates diabetic retinopathy by preventing retinal inflammation and the decreased expression of tight junction protein. International Journal of Ophthalmology. 2017, 10: 870-877. (1.177)

Chen T, Kan YJ, Chou GX*, Zhang CG. A new highly oxygenated pregnane and two new 5-hydroxymethylfurfural derivatives from the water decoction of Poria cocos. Journal of Asian Natural Products Research. 2017, 4340869. (1.071)